Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …

Atherosclerosis is the primary cause of cardiovascular diseases, such as myocardial
infarction and stroke, which account for the highest death toll worldwide. Macrophage is the …

Aortic aneurysm and dissection (AAD) are leading causes of death in the elderly. Recent
studies have demonstrated that silicate ions can manipulate multiple cells, especially …

ABSTRACT Background and Purpose Substitution of Cys674 (C674) in the sarcoplasmic/
endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads …

Myocardial infarction (MI) is a leading cause of death worldwide. Few drugs hold the ability
to depress cardiac electrical and structural remodeling simultaneously after MI, which is …

Background and aims Angiotensin II (Ang II) is commonly used to induce aortic aneurysm
and atherosclerosis in animal models. Ang II upregulates NADPH oxidase isoform Nox4 in …

Abstract Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain
intracellular calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating …

Atherosclerosis continues to be a leading cause of morbidity and mortality globally. The
precise evaluation of the extent of an atherosclerotic plaque is essential for forecasting its …

Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary
vascular remodeling, in which hyperproliferation of pulmonary artery smooth muscle cells …

Background and Purpose Inactivation of Cys674 (C674) in the sarcoplasmic/endoplasmic
reticulum Ca2+ ATPase 2 (SERCA2) causes intracellular Ca2+ accumulation, which …