Anxiolytic and antidepressive potentials of rosmarinic acid: A review with a focus on antioxidant and anti-inflammatory effects

A Dahchour - Pharmacological Research, 2022 - Elsevier
Depression and anxiety are the most prevalent neuropsychiatric disorders that have
emerged as global health concerns. Anxiolytic and antidepressant drugs, such as …

Potential applications of NRF2 inhibitors in cancer therapy

E Panieri, L Saso - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway

J Tang, L Xu, Y Zeng, F Gong - International immunopharmacology, 2021 - Elsevier
Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal
microflora disorder affect lung diseases through the gut-lung axis. In this study, we explored …

[HTML][HTML] Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute …

L Kong, J Deng, X Zhou, B Cai, B Zhang, X Chen… - Cell death & …, 2021 - nature.com
Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT)
is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its …

[HTML][HTML] Nrf2 attenuates ferroptosis-mediated IIR-ALI by modulating TERT and SLC7A11

H Dong, Y Xia, S Jin, C Xue, Y Wang, R Hu… - Cell death & …, 2021 - nature.com
Acute lung injury (ALI) carries a mortality rate of~ 50% and is a hot topic in the world of
critical illness research. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical …

Exosomes from adipose-derived stem cells alleviate the inflammation and oxidative stress via regulating Nrf2/HO-1 axis in macrophages

K Shen, Y Jia, X Wang, J Zhang, K Liu, J Wang… - Free Radical Biology …, 2021 - Elsevier
ADSCs exosomes, an important means of intercellular communication, can regulate an
array of biological processes, including promoting tissue repairs and regeneration, and …

Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis

JY Kang, MM Xu, Y Sun, ZX Ding, YY Wei… - International …, 2022 - Elsevier
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is featured by intensive
inflammatory responses and oxidative stress, which lead to cytokine storms and pyroptosis …

[HTML][HTML] Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis

Y Qiu, B Wan, G Liu, Y Wu, D Chen, M Lu, J Chen… - Respiratory …, 2020 - Springer
Background Ferroptosis is a new type of nonapoptotic cell death model that was closely
related to reactive oxygen species (ROS) accumulation. Seawater drowning-induced acute …

[HTML][HTML] Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury

R Zhao, L Wang, T Wang, P Xian, H Wang… - Journal of Controlled …, 2022 - Elsevier
Mesenchymal stem cell-derived small extracellular vesicles (MSC-EVs) are promising
nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal …

Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

M Sadrkhanloo, M Entezari, S Orouei, A Zabolian… - Life Sciences, 2022 - Elsevier
The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance
and it responds to various cell stresses that oxidative stress is the most well-known one. The …