Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and
zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have …

Background: Melatonin (MLT) is a pleiotropic neurohormone controlling many physiological
processes and whose dysfunction may contribute to several different diseases, such as …

Melatonin is a pleiotropically acting regulator molecule, which influences numerous
physiological functions. Its secretion by the pineal gland progressively declines by age …

Melatonin MT1 and MT2 receptor ligands have been vigorously explored for the last 4
decades. Inspection of approximately 80 publications in the field revealed that most …

Neuropathic pain is an important public health problem for which only a few treatments are
available. Preclinical studies show that melatonin (MLT), a neurohormone acting on MT1 …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …

Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety. Most
of the physiological actions of MLT in the brain are mediated by two high-affinity G-protein …

An efficient, one-pot reductive alkylation of indoles with N-protected aminoethyl acetals in
the presence of TES/TFA is reported. It represents the first general method for the direct …

The CNS is both source and target of melatonin. This methoxyindole formed in the pineal
gland is also produced in other CNS regions and additionally enters the brain by uptake …