The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor‐associated macrophages

D Capece, M Fischietti, D Verzella… - BioMed research …, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

The tumor microenvironment in hepatocellular carcinoma

GC Leonardi, S Candido… - International …, 2012 - spandidos-publications.com
The tumor microenvironment has been largely studied as a dynamic system orchestrated by
inflammatory cells, including cancer cells, stroma as well as the extracellular matrix. It is …

Components of the hepatocellular carcinoma microenvironment and their role in tumor progression

MV Novikova, NV Khromova, PB Kopnin - Biochemistry (Moscow), 2017 - Springer
This review summarizes recently published data on the mechanisms of tumor cell interaction
with the tumor microenvironment. Tumor stroma influences the processes of …

A review of cancer genetics and genomics studies in Africa

SO Rotimi, OA Rotimi, B Salhia - Frontiers in oncology, 2021 - frontiersin.org
Cancer is the second leading cause of death globally and is projected to overtake infectious
disease as the leading cause of mortality in Africa within the next two decades. Cancer is a …

Influence of transforming growth factor-β1 and tumor necrosis factor-α genes polymorphisms on the development of cirrhosis and hepatocellular carcinoma in chronic …

MI Radwan, HF Pasha, RH Mohamed, HIM Hussien… - Cytokine, 2012 - Elsevier
BACKGROUND: Host genetic factors may affect clinical outcomes of hepatitis C virus (HCV)
infection; however, the possible mechanisms remain largely unknown. This study aimed to …

[HTML][HTML] Alcoholic liver disease and hepatitis C virus infection

I Novo-Veleiro, L Alvela-Suárez… - World journal of …, 2016 - ncbi.nlm.nih.gov
Alcohol consumption and hepatitis C virus (HCV) infection have a synergic hepatotoxic
effect, and the coexistence of these factors increases the risk of advanced liver disease. The …

High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C

D Aroucha, RF Do Carmo, P Moura, JLA Silva… - Cytokine, 2013 - Elsevier
Hepatitis C virus (HCV) is the main cause of chronic liver disease, cirrhosis and
hepatocellular carcinoma (HCC) worldwide. The risk for the development of HCC increases …

[HTML][HTML] Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms

MF Dondeti, EA El-Maadawy… - World journal of …, 2016 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a primary liver cancer, which is one of the most prevalent
cancers among humans. Many factors are involved in the liver carcinogenesis as lifestyle …

Exploring the Impact of Different Inflammatory Cytokines on Hepatitis C Virus Infection

NG Bader El Din, S Farouk - Journal of Interferon & Cytokine …, 2024 - liebertpub.com
Hepatitis C virus (HCV) infection is a global health concern affecting millions worldwide.
Chronic HCV infection often leads to liver inflammation and can progress to cirrhosis and …

TNF‐α and IL‐10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals

DC Aroucha, RF Carmo… - Journal of medical …, 2016 - Wiley Online Library
Hepatitis C virus (HCV) is the major cause of hepatocellular carcinoma (HCC). The risk to
develop HCC increases with the severity of liver inflammation and hepatic fibrosis. It is …