Cancer-associated fibroblasts: Origin, function, imaging, and therapeutic targeting

R Rimal, P Desai, R Daware, A Hosseinnejad… - Advanced drug delivery …, 2022 - Elsevier
The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

A water‐soluble AIEgen for noninvasive diagnosis of kidney fibrosis via SWIR fluorescence and photoacoustic imaging

D Yan, T Li, Y Yang, N Niu, D Wang, J Ge… - Advanced …, 2022 - Wiley Online Library
Early diagnosis of renal fibrosis is crucially significant on account of its worldwide prevalent
tendency. Optical imaging in the near‐infrared window has been recognized as an …

Cellular and molecular mechanisms of kidney fibrosis

S Djudjaj, P Boor - Molecular aspects of medicine, 2019 - Elsevier
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Extracellular matrix in kidney fibrosis: more than just a scaffold

RD Bülow, P Boor - Journal of Histochemistry & …, 2019 - journals.sagepub.com
Kidney fibrosis is the common histological end-point of progressive, chronic kidney diseases
(CKDs) regardless of the underlying etiology. The hallmark of renal fibrosis, similar to all …

Location, location, location: how the tissue microenvironment affects inflammation in RA

CD Buckley, C Ospelt, S Gay… - Nature Reviews …, 2021 - nature.com
Current treatments for rheumatoid arthritis (RA) do not work well for a large proportion of
patients, or at all in some individuals, and cannot cure or prevent this disease. One major …

Kidney fibrosis: Emerging diagnostic and therapeutic strategies

BM Klinkhammer, P Boor - Molecular Aspects of Medicine, 2023 - Elsevier
An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

M Walraven, B Hinz - Matrix Biology, 2018 - Elsevier
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …

Recent advances in medical image processing for the evaluation of chronic kidney disease

I Alnazer, P Bourdon, T Urruty, O Falou, M Khalil… - Medical Image …, 2021 - Elsevier
Assessment of renal function and structure accurately remains essential in the diagnosis
and prognosis of Chronic Kidney Disease (CKD). Advanced imaging, including Magnetic …

Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF‐β1/Smad3 and TGF‐β1/p38 MAPK Pathways

N Liu, J Feng, X Lu, Z Yao, Q Liu, Y Lv… - Mediators of …, 2019 - Wiley Online Library
Objective. Liver fibrosis is a consequence of wound‐healing responses to chronic liver insult
and may progress to liver cirrhosis if not controlled. This study investigated the protection …