Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …

Ca2+-activated K+ channels are critical to cellular Ca2+ homeostasis and excitability; they
couple intracellular Ca2+ and membrane voltage change. Of these, the small, 4–14 pS …

Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable of
impacting cognition in some patients with post-acute sequelae of SARS-CoV-2 (PASC). To …

Introduction The entorhinal cortex is among the earliest areas involved in Alzheimer's
disease. Volume reduction and neural loss in this area have been widely reported. Human …

Senescent microglia are a distinct microglial phenotype present in aging brain that have
been implicated in the progression of aging and age-related neurodegenerative diseases …

Abstract Background As Alzheimer's disease (AD) pathology presents decades before
dementia manifests, unbiased biomarker cut-points may more closely reflect presence of …

The soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor
(SNARE) proteins play a central role in most forms of intracellular membrane trafficking, a …

Alzheimer's disease (AD) is an insidious, multifactorial disease that involves the devastation
of neurons leading to cognitive impairments. Alzheimer's have compounded pathologies of …

Many physiological processes in the human body follow a 24-h circadian rhythm controlled
by the circadian clock system. Light, sensed by retina, is the predominant “zeitgeber” able to …