[HTML][HTML] Advances in decomposing complex metabolite mixtures using substructure-and network-based computational metabolomics approaches

MA Beniddir, KB Kang, G Genta-Jouve, F Huber… - Natural product …, 2021 - pubs.rsc.org
Covering: up to the end of 2020 Recently introduced computational metabolome mining
tools have started to positively impact the chemical and biological interpretation of …

Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities

LK Caesar, R Montaser, NP Keller… - Natural product reports, 2021 - pubs.rsc.org
Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …

[HTML][HTML] Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Fingerprinting and profiling in metabolomics of biosamples

V Ghini, G Meoni, A Vignoli, F Di Cesare… - Progress in Nuclear …, 2023 - Elsevier
This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

[HTML][HTML] Current landscape of methods to evaluate antimicrobial activity of natural extracts

R Gonzalez-Pastor, SE Carrera-Pacheco… - Molecules, 2023 - mdpi.com
Natural extracts have been and continue to be used to treat a wide range of medical
conditions, from infectious diseases to cancer, based on their convenience and therapeutic …

Artificial intelligence-guided discovery of anticancer lead compounds from plants and associated microorganisms

G Li, P Lin, K Wang, CC Gu, S Kusari - Trends in Cancer, 2022 - cell.com
Plants and associated microorganisms are essential sources of natural products against
human cancer diseases, partly exemplified by plant-derived anticancer drugs such as Taxol …

Dereplication of fungal metabolites by NMR-based compound networking using MADByTE

L Flores-Bocanegra, ZY Al Subeh… - Journal of natural …, 2022 - ACS Publications
Strategies for natural product dereplication are continually evolving, essentially in lock step
with advances in MS and NMR techniques. MADByTE is a new platform designed to identify …

Synergy between machine learning and natural products cheminformatics: Application to the lead discovery of anthraquinone derivatives

S Moshawih, HP Goh, N Kifli, AC Idris… - Chemical Biology & …, 2022 - Wiley Online Library
Cheminformatics utilizing machine learning (ML) techniques have opened up a new horizon
in drug discovery. This is owing to vast chemical space expansion with rocketing numbers of …

Marine indole alkaloid diversity and bioactivity. What do we know and what are we missing?

DC Holland, AR Carroll - Natural Product Reports, 2023 - pubs.rsc.org
Covering: marine indole alkaloids (n= 2048) and their reported bioactivities up to the end of
2021 Despite increasing numbers of marine natural products (MNPs) reported each year …

[HTML][HTML] Modern trends in natural antibiotic discovery

AA Baranova, VA Alferova, VA Korshun, AP Tyurin - Life, 2023 - mdpi.com
Natural scaffolds remain an important basis for drug development. Therefore, approaches to
natural bioactive compound discovery attract significant attention. In this account, we …