The role of CYP3A in health and disease
LS Klyushova, ML Perepechaeva, AY Grishanova - Biomedicines, 2022 - mdpi.com
CYP3A is an enzyme subfamily in the cytochrome P450 (CYP) superfamily and includes
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
isoforms CYP3A4, CYP3A5, CYP3A7, and CYP3A43. CYP3A enzymes are indiscriminate …
GSK3: a kinase balancing promotion and resolution of inflammation
L Hoffmeister, M Diekmann, K Brand, R Huber - Cells, 2020 - mdpi.com
GSK3 has been implicated for years in the regulation of inflammation and addressed in a
plethora of scientific reports using a variety of experimental (disease) models and …
plethora of scientific reports using a variety of experimental (disease) models and …
[HTML][HTML] Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss
Bone is maintained by coupled activities of bone-forming osteoblasts/osteocytes and bone-
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
resorbing osteoclasts. Alterations in this relationship can lead to pathologic bone loss such …
[HTML][HTML] SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
D Wendisch, O Dietrich, T Mari, S von Stillfried… - Cell, 2021 - cell.com
Summary COVID-19-induced" acute respiratory distress syndrome"(ARDS) is associated
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …
with prolonged respiratory failure and high mortality, but the mechanistic basis of lung injury …
Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an extended
polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia …
polyglutamine repeat in the N terminus of the Huntingtin protein (HTT). Reactive microglia …
Recurrent somatic mutations in regulatory regions of human cancer genomes
Aberrant regulation of gene expression in cancer can promote survival and proliferation of
cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome …
cancer cells. Here we integrate whole-genome sequencing data from The Cancer Genome …
Single-cell RNA sequencing identifies candidate renal resident macrophage gene expression signatures across species
Background Resident macrophages regulate homeostatic and disease processes in
multiple tissues, including the kidney. Despite having well defined markers to identify these …
multiple tissues, including the kidney. Despite having well defined markers to identify these …
Inferring gene regulatory network from single-cell transcriptomes with graph autoencoder model
The gene regulatory structure of cells involves not only the regulatory relationship between
two genes, but also the cooperative associations of multiple genes. However, most gene …
two genes, but also the cooperative associations of multiple genes. However, most gene …
The m6A reader IMP2 directs autoimmune inflammation through an IL-17– and TNFα-dependent C/EBP transcription factor axis
Excessive cytokine activity underlies many autoimmune conditions, particularly through the
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
interleukin-17 (IL-17) and tumor necrosis factor–α (TNFα) signaling axis. Both cytokines …
Mechanisms of the acute effects of inhaled ozone in humans
PA Bromberg - Biochimica et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Ambient air ozone (O 3) is generated photochemically from oxides of nitrogen and volatile
hydrocarbons. Inhaled O 3 causes remarkably reversible acute lung function changes and …
hydrocarbons. Inhaled O 3 causes remarkably reversible acute lung function changes and …