The prime task of nociceptors is the transformation of noxious stimuli into action potentials
that are propagated along the neurites of nociceptive neurons from the periphery to the …

Inflammation is one of the main causes of pathologic pain. Knowledge of the molecular links
between inflammatory signals and pain-mediating neuronal signals is essential for …

Paclitaxel (PTX) is a frequently used anticancer drug that causes peripheral neuropathy.
Transient receptor potential ankyrin 1 (TRPA1), a plasma membrane calcium channel, has …

Alzheimer's disease is the most common form of dementia, it is estimated to affect over 40
million people worldwide. Classically, the disease has been characterized by the …

Pain caused by the tumor or aromatase inhibitors (AIs) is a disabling symptom in breast
cancer survivors. Their mechanisms are unclear, but pro-algesic and inflammatory …

Abstract Background Cinnamomum cassia (L.) J. Presl (Cinnamon) was known as a kind of
hot herb, improved circulation and warmed the body. However, the active components and …

Earlier studies indicate that the central nucleus of the amygdala (CeA) contributes to
neuropathic pain. Here we studied whether amygdaloid administration of antioxidants or …

Anastrozole, an aromatase inhibitor, induces painful musculoskeletal symptoms, which
affect patients' quality of life and lead to therapy discontinuation. Efforts have been made to …

Aromatase inhibitors (AIs) cause symptoms of musculoskeletal pain, and some mechanisms
have been proposed to explain them. However, signaling pathways downstream from kinin …

Pain and pain management in the elderly population is a significant social and medical
problem. Pain sensation is a complex phenomenon that typically involves activation of …