Background: The role of humoral immunity has been well established in reducing infection
risk and facilitating viral clearance in patients with COVID-19. However, the relationship …

Objective. To perform a systematic literature review (SLR) on the association of common
variable immunodeficiency (CVID) and rare and complex connective tissue and …

Purpose Limited data is available on the effect of COVID-19 vaccination in
immunocompromised individuals. Here, we provide the results from vaccinating a single …

Common variable immunodeficiency disorders (CVID), the most common primary immune
deficiency, includes heterogeneous syndromes characterized by hypogammaglobulinemia …

Mutations in the recombination activating gene 1 (RAG1) and RAG2 in humans are
associated with a broad spectrum of clinical phenotypes, from severe combined …

Predominantly antibody deficiencies (PADs) are inborn disorders characterized by immune
dysregulation and increased susceptibility to infections. Response to vaccination, including …

In the last two decades two new paradigms changed our way of perceiving primary
immunodeficiencies: An increasing number of immune defects are more associated with …

Introduction Common variable immunodeficiency (CVID) is the most common symptomatic
primary immunodeficiency. Due to the wide spectrum of the CVID manifestations, the …

Background Patients with immunodeficiencies commonly experience diagnostic delays
resulting in morbidity. There is an unmet need to identify patients earlier, especially those …

Background Common variable immunodeficiency (CVID) has been recognised as the most
common primary immunodeficiency in adulthood, and is characterised by increased …