Plumbagin, a natural compound with several biological effects and anti-inflammatory properties

G Petrocelli, P Marrazzo, L Bonsi, F Facchin, F Alviano… - Life, 2023 - mdpi.com
Phytochemicals from various medicinal plants are well known for their antioxidant properties
and anti-cancer effects. Many of these bioactive compounds or natural products have …

The use of combination therapy for the improvement of colistin activity against bacterial biofilm

AT Jalil, RTA Alrawe, MA Al-Saffar… - Brazilian Journal of …, 2024 - Springer
Colistin is used as a last resort for the management of infections caused by multi-drug
resistant (MDR) bacteria. However, the use of this antibiotic could lead to different side …

Antibacterial type-II InP/ZnO quantum dots via multimodal reactive oxygen species

SU Khan, GO Eren, N Atac, A Onal, MH Qureshi… - Chemical Engineering …, 2024 - Elsevier
The emergence of multidrug-resistant bacteria as a global health threat has necessitated the
exploration of alternative treatments to combat bacterial infections. Among these …

A potential strategy against clinical carbapenem-resistant Enterobacteriaceae: antimicrobial activity study of sweetener-decorated gold nanoparticles in vitro and in …

H Liu, Z Huang, H Chen, Y Zhang, P Yu, P Hu… - Journal of …, 2023 - Springer
Abstract Background Carbapenem-resistant Enterobacteriaceae (CRE) present substantial
challenges to clinical intervention, necessitating the formulation of novel antimicrobial …

PYED-1 Overcomes Colistin Resistance in Acinetobacter baumannii

M Stabile, A Esposito, VD Iula, A Guaragna… - Pathogens, 2023 - mdpi.com
Antibiotic resistance has become more and more widespread over the recent decades,
becoming a major global health problem and causing colistin to be increasingly used as an …

Thymol-decorated gold nanoparticles for curing clinical infections caused by bacteria resistant to last-resort antibiotics

Z Huang, X Zhang, Z Yao, Y Han, J Ye, Y Zhang… - MSphere, 2023 - Am Soc Microbiol
Multidrug-resistant bacteria pose a tremendous challenge to public health worldwide. Many
bacteria resistant to last-resort antibiotics due to antibiotic misuse have been recently …

Plumbagin inhibits fungal growth, HMGB1/LOX-1 pathway and inflammatory factors in A. fumigatus keratitis

F Cong, L Gu, J Lin, G Liu, Q Wang, L Zhang… - Frontiers in …, 2024 - frontiersin.org
To investigate the anti-inflammatory and antifungal effects of plumbagin (PL) in Aspergillus
fumigatus (A. fumigatus) keratitis, the minimum inhibitory concentration (MIC), time-killing …

Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo

H Liu, Y Zhang, Z Zhong, Y Gong, P Yu, Y Yang… - International Journal of …, 2024 - Elsevier
Objectives Colistin (COL) was once considered to be the last line of defence against
multidrug-resistant bacteria belonging to the family Enterobacteriaceae. Due to the misuse …

[HTML][HTML] Potent anti-biofilm properties of plumbagin against fluconazole-resistant Candida auris

HW Jin, YB Eom - Journal of Traditional and Complementary Medicine, 2024 - Elsevier
Background and aim The escalation of fungal infections is driving an increase in disease
and mortality rates. In particular, the emergence of Candida auris (C. auris), which shows …

Plumbagin enhances antimicrobial and anti-biofilm capacities of chlorhexidine against clinical Klebsiella pneumoniae while reducing resistance mutations

H Liu, H Chen, Z Ma, Y Zhang, S Zhang… - Microbiology …, 2024 - journals.asm.org
With the widespread misuse of disinfectants, the clinical susceptibility of Klebsiella
pneumoniae (K. pneumoniae) to chlorhexidine (CHX) has gradually diminished, posing …