Discovery of Highly Efficient Novel Antifungal Lead Compounds Targeting Succinate Dehydrogenase: Pyrazole-4-carboxamide Derivatives with an N-Phenyl …

XP Sun, CS Yu, LJ Min, CL Cantrell… - Journal of Agricultural …, 2023 - ACS Publications
Developing environmentally friendly fungicides is crucial to tackle the issue of rising
pesticide resistance. In this study, a series of novel pyrazole-4-carboxamide derivatives …

Design, synthesis, and antifungal activities of novel pyrazole-4-carboxamide derivatives containing an ether group as potential succinate dehydrogenase inhibitors

B Luo, Y Zhao, J Zhang, W Li, M Liu… - Journal of Agricultural …, 2023 - ACS Publications
A series of novel pyrazole-4-carboxamides bearing an ether group were designed and
synthesized on the basis of the structure of commercial succinate dehydrogenase inhibitor …

Discovery of terpene-derived quaternary ring compounds containing an oxime moiety as potential fungicides

T Pan, J Ye, J Li, K Gui, J Li, J Feng, Z Ma… - Journal of Agricultural …, 2023 - ACS Publications
Terpene-derived quaternary ring compounds with an oxime moiety were designed and
prepared to create fungicides from natural products. A preliminary assessment of their …

Discovery of pyrazole-5-yl-amide derivatives containing cinnamamide structural fragments as potential succinate dehydrogenase inhibitors

X Cheng, Z Xu, H Cui, Z Zhang, W Chen… - Journal of Agricultural …, 2023 - ACS Publications
To promote the development of novel agricultural succinate dehydrogenase inhibitor (SDHI)
fungicides, we introduced cinnamamide and nicotinamide structural fragments into the …

Heterocycle-substituted α-methylene-γ-butyrolactones derivatives synthesis, antifungal activity, and 3D-QSAR

L Li, D Yang, H Li, G Chen, P Lei, Y Gao… - Journal of Agricultural …, 2023 - ACS Publications
Developing fungicides from active botanical skeletons is one of the effective methods to
tackle the resistance of plant pathogens. Based on our previous discoveries, a series of …

Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi

YH Zhang, SS Yang, Q Zhang, TT Zhang… - Journal of Agricultural …, 2023 - ACS Publications
Based on the structural features of both succinate dehydrogenase inhibitors (SDHIs) and
targeted covalent inhibitors, a series of N-phenylpropiolamides containing a Michael …

Design, Synthesis, and Study of the Dual Action Mode of Novel N-Thienyl-1,5-disubstituted-4-pyrazole Carboxamides against Nigrospora oryzae

C Zhang, C Zhao, H Zheng, L Li… - Journal of Agricultural …, 2023 - ACS Publications
Due to the single target but extensive application of commercialized succinate
dehydrogenase inhibitors (SDHIs), resistance problems have gradually become apparent in …

Design, synthesis, and biological evaluation of novel pyrazol-5-yl-benzamide derivatives containing oxazole group as potential succinate dehydrogenase inhibitors

X Cheng, Z Xu, H Luo, X Chang… - Journal of Agricultural and …, 2022 - ACS Publications
A series of pyrazol-5-yl-benzamide derivatives containing the oxazole group were designed
and synthesized as potential SDH inhibitors. According to the results of the bioassays, most …

Discovery of aryloxy-, arylthio-, and arylamino-containing acethydrazides as fungicidal agents

H Fang, Z Chen, Y Liu, T Zhang, J Chang… - Journal of Agricultural …, 2022 - ACS Publications
The development of new green fungicides is an effective way to solve the resistance of
agricultural pathogens and plays an important role in promoting high-quality and …

Discovery of novel pyrazol-5-yl-benzamide derivatives containing a thiocyanato group as broad-spectrum fungicidal candidates

Y Li, H Yang, Y Ma, Y Cao, D Xu, X Liu… - Journal of Agricultural …, 2023 - ACS Publications
In an effort to promote the development of new fungicides, a series of 48 novel N-(1-methyl-4-
thiocyanato-1 H-pyrazol-5-yl)-benzamide derivatives A1–A36 and B1–B12 were designed …