Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Epigenetic changes such as DNA methylation act to regulate gene expression in normal
mammalian development. However, promoter hypermethylation also plays a major role in …

Epigenetic and genetic alterations contribute to cancer initiation and progression.
Epigenetics refers to the study of heritable changes in gene expression without alterations in …

Inactivation of tumour suppressor genes is central to the development of all common forms
of human cancer 1. This inactivation often results from epigenetic silencing associated with …

Gene silencing in eukaryotes is associated with the formation of heterochromatin, a complex
of proteins and DNA that block transcription. Heterochromatin is characterized by the …

A striking link exists between advanced age and increased incidence of cancer. Here I
review how several of the age-related molecular and physiological changes might act in …

Rationale: Prenatal exposure to tobacco smoke increases the risk for diseases later in the
child's life that may be mediated through alterations in DNA methylation. Objectives: To …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

The demand for high-quality milk is increasing worldwide. The efficiency of milk synthesis
can be improved by taking advantage of the accumulated knowledge of the transcriptional …

In the cell, Dnmt1 is the major enzyme in maintenance of the pattern of DNA methylation
after DNA replication. Evidence suggests that the protein is located at the replication fork …