The clinical approach to patients with amyotrophic lateral sclerosis (ALS) has been largely
modified by the identification of novel genes, the detection of gene mutations in apparently …

Background Mutations in the genes called BRCA1 and BRCA2 are associated with
significantly elevated lifetime risk of developing breast and ovarian cancer. This year marks …

Objective The objectives of this study are to determine (i) what daughters, ages 18–24 years,
of BRCA1/2 mutation carriers understand about their 50% chance of carrying a BRCA1/2 …

There is significant controversy over whether patients have a 'right not to know'information
relevant to their health. Some arguments for limiting such a right appeal to potential burdens …

In unselected populations, less than 10% of breast cancers are associated with germline
mutations in predisposing genes. Breast cancer type 1 and 2 (BRCA1 and BRCA2) …

Abstract The Ontario Breast Screening Program for women with a genetic predisposition to
breast cancer is one of the first international models of a government-funded public health …

Abstract Knowledge, attitudes, and patient preferences about genetic testing and
subsequent risk management for cancer prevention among average risk populations are …

Purpose: Mutational load of susceptibility variants has not been studied on a genomic scale
in a clinical population, nor has the potential to identify these mutations as incidental …

Background Identifying genetic disease-susceptible individuals through population
screening is considered as a promising approach for disease prevention. DNA mismatch …

Background When a woman is diagnosed with hereditary breast or ovarian cancer, family
members may be at high risk of cancers associated with BRCA1/2 gene mutation and …