Gabapentin is an anti-epileptic agent but now it is also recommended as first line agent in
neuropathic pain, particularly in diabetic neuropathy and post herpetic neuralgia. α2δ-1, an …

Pain is a common complication in patients following spinal cord injury (SCI), with studies
citing up to 80% of patients reporting some form of pain. Neuropathic pain (NP) makes up a …

Objective: To assess the efficacy and tolerability of pregabalin for the treatment of central
neuropathic pain after spinal cord injury (SCI). Methods: Patients with chronic, below-level …

Sports and orthopaedic physical therapists have long used a multitude of techniques in
order to address pain and dysfunction associated with myofascial trigger points. One …

Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common
and debilitating consequence of a lot of disorders and diseases. The management of …

The role of microglia and their contribution to the development and maintenance of pain
states has emerged as an attractive field of study. Sensitization of central nociceptors and …

Background/Purpose The present study was designed to investigate the potential of sodium
butyrate, a histone deacetylase (HDAC) inhibitor, in chronic constriction injury (CCI)-induced …

Peripheral nerve injuries (PNIs) may result in cellular and molecular changes in supraspinal
structures possibly involved in neuropathic pain (NPP) maintenance. Activated glial cells in …

The treatment of patients with chronic painful conditions can at times be difficult at best.
Historically, the opiates were the primary class of medications used to treat patients with …

Background Pain is a complex mechanism which involves different systems, including the
opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents …