▪ Abstract The detection of painful stimuli occurs primarily at the peripheral terminals of
specialized sensory neurons called nociceptors. These small-diameter neurons transduce …

The clinical use of TRPV1 (transient receptor potential vanilloid subfamily, member 1; also
known as VR1) antagonists is based on the concept that endogenous agonists acting on …

We have compared activation by heat of TRPV4 channels, heterogeneously expressed in
HEK293 cells, and endogenous channels in mouse aorta endothelium (MAEC). Increasing …

Abstract TRPV1 is a Ca2+-permeable channel studied mostly as a pain receptor in sensory
neurons. However, its role in other cell types is poorly understood. Here we found that …

Nonsteroid anti-inflammatory drugs (NSAIDs) are major drugs against inflammation and
pain. They are well known inhibitors of cyclooxygenases (COXs). However, many studies …

Changes in membrane tension resulting from membrane stretch represent one of the key
elements in blood flow regulation in vascular smooth muscle. However, the molecular …

Living organisms must evaluate changes in environmental and internal temperatures to
mount appropriate physiological and behavioral responses conducive to survival. Classical …

Capsaicin, a major ingredient of hot pepper, was considered to exhibit an anti-inflammatory
property. In order to clarify the signalling mechanism underlying the anti-inflammatory action …

The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non‐selective cation
channel that recently has been shown in human keratinocytes in vitro and in vivo. However …

Following cloning of the vanilloid receptor 1 (VR1) at least four other related proteins have
been identified. Together, these form a distinct subgroup of the transient receptor potential …