Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway
diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation …

Rationale: Accurate prediction of mortality helps select patients for interventions aimed at
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …

Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre
observational study of chronic obstructive pulmonary disease (COPD) designed to guide …

Background Patients with chronic obstructive pulmonary disease (COPD) have few options
for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have …

Asthma and chronic obstructive pulmonary disease (COPD) represent two classes of chronic
obstructive lung disorders that may share some similar immunologic mechanisms of …

Airway epithelium is the first line of defense against exposure of the airway and lung to
various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an …

The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …

Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β 2-agonists
is highly effective, safe and relatively inexpensive, but for many patients, their disease …

Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of
airflow limitation on spirometry, yet subjects with COPD can have marked differences in …