Systemic manifestations and comorbidities of COPD
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …
complex disease involving more than airflow obstruction. Airflow obstruction has profound …
The cytokine network in chronic obstructive pulmonary disease
PJ Barnes - American journal of respiratory cell and molecular …, 2009 - atsjournals.org
Multiple cytokines play a role in the orchestration of inflammation in inflammatory airway
diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation …
diseases, such as chronic obstructive pulmonary disease, through the recruitment, activation …
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease
BR Celli, N Locantore, J Yates… - American journal of …, 2012 - atsjournals.org
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …
Design of the subpopulations and intermediate outcomes in COPD study (SPIROMICS)
D Couper, LM LaVange, ML Han, RG Barr, E Bleecker… - Thorax, 2014 - thorax.bmj.com
Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre
observational study of chronic obstructive pulmonary disease (COPD) designed to guide …
observational study of chronic obstructive pulmonary disease (COPD) designed to guide …
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
LM Fabbri, PMA Calverley, JL Izquierdo-Alonso… - The Lancet, 2009 - thelancet.com
Background Patients with chronic obstructive pulmonary disease (COPD) have few options
for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have …
for treatment. The efficacy and safety of the phosphodiesterase-4 inhibitor roflumilast have …
TH17 Cells in Asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) represent two classes of chronic
obstructive lung disorders that may share some similar immunologic mechanisms of …
obstructive lung disorders that may share some similar immunologic mechanisms of …
[HTML][HTML] Airway epithelial cell cilia and obstructive lung disease
A Yaghi, MB Dolovich - Cells, 2016 - mdpi.com
Airway epithelium is the first line of defense against exposure of the airway and lung to
various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an …
various inflammatory stimuli. Ciliary beating of airway epithelial cells constitutes an …
The functional significance behind expressing two IL–8 receptor types on PMN
The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …
has led to interest in whether each receptor type contributes to unique functions. PMN are …
New therapies for asthma: is there any progress?
PJ Barnes - Trends in pharmacological sciences, 2010 - cell.com
Current therapy for asthma with inhaled corticosteroids and long-acting inhaled β 2-agonists
is highly effective, safe and relatively inexpensive, but for many patients, their disease …
is highly effective, safe and relatively inexpensive, but for many patients, their disease …
A genome-wide association study of emphysema and airway quantitative imaging phenotypes
Rationale: Chronic obstructive pulmonary disease (COPD) is defined by the presence of
airflow limitation on spirometry, yet subjects with COPD can have marked differences in …
airflow limitation on spirometry, yet subjects with COPD can have marked differences in …