Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications

X Zhou, X Ao, Z Jia, Y Li, S Kuang, C Du… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the most frequently diagnosed malignant diseases worldwide, posing a
serious, long-term threat to patients' health and life. Systemic chemotherapy remains the first …

Long non-coding RNAs (lncRNAs) signaling in cancer chemoresistance: from prediction to druggability

GC Eptaminitaki, D Stellas, B Bonavida… - Drug Resistance Updates, 2022 - Elsevier
The acquisition of cancer cell resistance to conventional chemotherapeutics is considered
the major driver of treatment failure and disease recurrence in most solid and hematological …

Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance

M Hashemi, S Hajimazdarany, CD Mohan… - Pharmacological …, 2022 - Elsevier
Epithelial-to-mesenchymal transition (EMT) is a process that involves the transformation of
polarized epithelial cells to attain a mesenchymal phenotype that presents an elevated …

The interactions between DNA methylation machinery and long non-coding RNAs in tumor progression and drug resistance

MJ Al-Imam, UAR Hussein, FF Sead, AMA Faqri… - DNA repair, 2023 - Elsevier
DNA methylation is one of the main epigenetic mechanisms in cancer development and
progression. Aberrant DNA methylation of CpG islands within promoter regions contributes …

Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets

M Hashemi, S Mirzaei, MA Zandieh, S Rezaei… - Progress in biophysics …, 2023 - Elsevier
Liver is an important organ in body that performs vital functions such as detoxification. Liver
is susceptible to development of cancers, and hepatocellular carcinoma (HCC) is among …

The interplay between noncoding RNAs and drug resistance in hepatocellular carcinoma: the big impact of little things

Y Fang, XL Zhang, HF Huang, Z Zeng - Journal of Translational Medicine, 2023 - Springer
Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in people, and
a common primary liver cancer. Lacking early diagnosis and a high recurrence rate after …

[HTML][HTML] miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma

VR Mallela, M Rajtmajerová, A Trailin, V Liška… - Non-coding RNA …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is primary liver cancer, frequently diagnosed at advanced
stages with limited therapeutic options. MicroRNAs (miRNAs) regulate target gene …

The pivotal role of EMT-related noncoding RNAs regulatory axes in hepatocellular carcinoma

AV Ghionescu, A Sorop, SO Dima - Frontiers in Pharmacology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) remains a major health problem worldwide, being the
leading cause of cancer-related deaths, with limited treatment options, especially in its …

Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis

Y Tian, M Zhang, L Liu, Z Wang, B Liu… - Frontiers in …, 2024 - frontiersin.org
Hepatocellular carcinoma (HCC) is a significant contributor to cancer-related deaths in the
world. The development and progression of HCC are closely correlated with the abnormal …

Hsa-miR-665 Is a Promising Biomarker in Cancer Prognosis

X Guan, KC Pavani, J Chunduru, BJG Broeckx… - Cancers, 2023 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small biomolecules that can indicate the
presence of certain diseases, including cancer. They are stable and can be easily detected …