Molecular aspects of insulin aggregation and various therapeutic interventions

A Das, M Shah, I Saraogi - ACS bio & med Chem Au, 2022 - ACS Publications
Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …

Insulin allergy: clinical manifestations and management strategies

L Heinzerling, K Raile, H Rochlitz, T Zuberbier… - Allergy, 2008 - Wiley Online Library
Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is
suspected upon noticing immediate symptoms following insulin injections. The immediate …

[HTML][HTML] Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting

E Marcello, V Chiono - International Journal of Molecular Sciences, 2023 - mdpi.com
Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …

Erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis

SM Breathnach - Rook's textbook of dermatology, 2010 - Wiley Online Library
Clinically, erythema multiforme involves macular, papular or urticarial lesions, as well as the
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …

Insulin allergy

MK Ghazavi, GA Johnston - Clinics in dermatology, 2011 - Elsevier
Insulin reactions occur rarely but are of tremendous clinical importance. The first was
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …

A preanodized 6B-pencil graphite as an efficient electrochemical sensor for mono-phenolic preservatives (phenol and meta-cresol) in insulin formulations

N Vishnu, AS Kumar - Analytical Methods, 2015 - pubs.rsc.org
Electrochemical oxidation of phenol on carbon electrodes has often been associated with
problems such as serious adsorption, formation of electro-inactive tarry polymers and …

Allergic shock and death associated with protamine administration in a diabetic patient

YQ Chu, LJ Cai, DC Jiang, D Jia, SY Yan, YQ Wang - Clinical therapeutics, 2010 - Elsevier
Background: Insulin is used to treat patients with both type 1 and type 2 diabetes mellitus.
Allergic reac-tions to insulin might be triggered by insulin itself or inactive ingredients in the …

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices

J Li, MK Chu, B Lu, S Mirzaie, K Chen… - Drug delivery and …, 2017 - Springer
Abstract Development of highly concentrated formulations of protein and peptide drugs is a
major challenge due to increased susceptibility to aggregation and precipitation. Numerous …

[HTML][HTML] Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine: a case report

C Pföhler, CSL Müller, DO Hasselmann… - Journal of Medical Case …, 2008 - Springer
Introduction Insulin allergy may occur in patients treated with subcutaneous applications of
insulin preparations. Besides additives in the insulin preparation such as protamine, cresol …

Delayed-type hypersensitivity reaction to the meta-cresol component of insulin

D Kim, J Baraniuk - Annals of Allergy, Asthma & Immunology, 2007 - Elsevier
BACKGROUND: Reactions to recombinant human insulin preparations occur at a rate of
2.4%. Although most have been traced to immunological reactions to the insulin, recent …