Molecular aspects of insulin aggregation and various therapeutic interventions
Protein aggregation leading to the formation of amyloid fibrils has various adverse effects on
human health ranging from fatigue and numbness to organ failure and death in extreme …
human health ranging from fatigue and numbness to organ failure and death in extreme …
Insulin allergy: clinical manifestations and management strategies
L Heinzerling, K Raile, H Rochlitz, T Zuberbier… - Allergy, 2008 - Wiley Online Library
Insulin allergy in patients with diabetes mellitus on insulin treatment is a rare condition. It is
suspected upon noticing immediate symptoms following insulin injections. The immediate …
suspected upon noticing immediate symptoms following insulin injections. The immediate …
[HTML][HTML] Biomaterials-enhanced intranasal delivery of drugs as a direct route for brain targeting
E Marcello, V Chiono - International Journal of Molecular Sciences, 2023 - mdpi.com
Intranasal (IN) drug delivery is a non-invasive and effective route for the administration of
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
drugs to the brain at pharmacologically relevant concentrations, bypassing the blood–brain …
Erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis
SM Breathnach - Rook's textbook of dermatology, 2010 - Wiley Online Library
Clinically, erythema multiforme involves macular, papular or urticarial lesions, as well as the
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …
Insulin allergy
MK Ghazavi, GA Johnston - Clinics in dermatology, 2011 - Elsevier
Insulin reactions occur rarely but are of tremendous clinical importance. The first was
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …
reported in 1922 as a callus reaction at the injection site of insufficiently purified bovine …
A preanodized 6B-pencil graphite as an efficient electrochemical sensor for mono-phenolic preservatives (phenol and meta-cresol) in insulin formulations
Electrochemical oxidation of phenol on carbon electrodes has often been associated with
problems such as serious adsorption, formation of electro-inactive tarry polymers and …
problems such as serious adsorption, formation of electro-inactive tarry polymers and …
Allergic shock and death associated with protamine administration in a diabetic patient
YQ Chu, LJ Cai, DC Jiang, D Jia, SY Yan, YQ Wang - Clinical therapeutics, 2010 - Elsevier
Background: Insulin is used to treat patients with both type 1 and type 2 diabetes mellitus.
Allergic reac-tions to insulin might be triggered by insulin itself or inactive ingredients in the …
Allergic reac-tions to insulin might be triggered by insulin itself or inactive ingredients in the …
Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices
Abstract Development of highly concentrated formulations of protein and peptide drugs is a
major challenge due to increased susceptibility to aggregation and precipitation. Numerous …
major challenge due to increased susceptibility to aggregation and precipitation. Numerous …
[HTML][HTML] Successful desensitization with human insulin in a patient with an insulin allergy and hypersensitivity to protamine: a case report
C Pföhler, CSL Müller, DO Hasselmann… - Journal of Medical Case …, 2008 - Springer
Introduction Insulin allergy may occur in patients treated with subcutaneous applications of
insulin preparations. Besides additives in the insulin preparation such as protamine, cresol …
insulin preparations. Besides additives in the insulin preparation such as protamine, cresol …
Delayed-type hypersensitivity reaction to the meta-cresol component of insulin
D Kim, J Baraniuk - Annals of Allergy, Asthma & Immunology, 2007 - Elsevier
BACKGROUND: Reactions to recombinant human insulin preparations occur at a rate of
2.4%. Although most have been traced to immunological reactions to the insulin, recent …
2.4%. Although most have been traced to immunological reactions to the insulin, recent …