Simple Summary Innate immune natural killer (NK) cells are capable of killing metastatic
cancer cells without activation by antigen-presenting cells beforehand. The cytotoxic effects …

Simple Summary Atherosclerosis is a critical cardiovascular disease associated with the use
of immune checkpoint inhibitors (ICIs). Proprotein convertase subtilisin/kexin type 9 (PCSK9) …

Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …

The cellular stress and immunity cycle is a cornerstone of organismal homeostasis. Stress
activates intracellular and intercellular communications within a tissue or organ to initiate …

Stroke is a severe and life-threatening disease, necessitating more research on new
treatment strategies. Infiltrated T lymphocytes, an essential adaptive immune cell with …

Siglecs are well known immunotherapeutic targets in cancer. Current checkpoint inhibitors
have exhibited limited efficacy, prompting a need for novel therapeutics for targets such as …

Breast cancer (BC), one of the most widespread and devastating diseases affecting women
worldwide, presents a significant public health challenge. This review explores the emerging …

Background: Osteosarcoma (OS) is the most frequently occurring malignant bone tumor in
humans, primarily affecting children and adolescents. Significant advancements in treatment …

Simple Summary Cancer treatment with immune checkpoint inhibitors (ICIs) has significantly
impacted patients' management and outcomes. To better assess the benefit of ICIs and …

Leukemia cells prevent immune system from clearing tumor cells by inducing the
immunosuppression of the bone marrow (BM) microenvironment. In recent years, further …