The microbial community is an important part of the natural ecosystem, and the quorum
sensing system is a momentous communication tool for the microbial community to connect …

Highlights•PAS domains are common sensing, signaling, dimerization, and localization
domains.•Sensing versatility derives from a conserved cleft that binds cofactors and …

Quorum sensing (QS) is a process of cell-to-cell communication that bacteria use to
orchestrate collective behaviors in response to changes in cell population density and …

The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease
cholera. The gut microbiome, or the native community of microorganisms found in the …

Quorum sensing (QS) serves as a vital means of intercellular signalling in a variety of
prokaryotes, which enables single cells to act in multicellular configurations. The potential to …

Quorum sensing is a chemical communication process in which bacteria use the production,
release, and detection of signal molecules called autoinducers to orchestrate collective …

The Aer2 receptor from Pseudomonas aeruginosa has an O2-binding PAS-heme domain
that stabilizes O2 via a Trp residue in the distal heme pocket. Trp rotates∼ 90° to bond with …

Quorum sensing is a bacterial communication process whereby bacteria produce, release,
and detect extracellular signaling molecules called autoinducers to coordinate collective …

ABSTRACT PAS domains are omnipresent building blocks of multidomain proteins in all
domains of life. Bacteria possess a variety of PAS domains in intracellular proteins and the …

Quorum sensing is a chemical communication process that bacteria use to coordinate group
behaviors. In the global pathogen Vibrio cholerae, one quorum-sensing receptor and …