Opioids are widely prescribed for pain management, and it is estimated that 40% of adults in
the United States use prescription opioids every year. Opioid misuse leads to high mortality …

The sleep of millions has suffered during the global COVID-19 pandemic. Prevalence rates
of 20–45% are reported globally for insomnia symptoms during the pandemic. Affected …

Background Hitherto only studies with selected populations have found an increased all-
cause mortality of some selected opioids compared to selected non-opioids for chronic non …

Background Opioid use for chronic non‐cancer pain (CNCP) is under debate. In the
absence of pan‐European guidance on this issue, a position paper was commissioned by …

Rationale: Central sleep apnea (CSA) is associated with high mortality. Current knowledge
stems from studies with limited sample size (fewer than 100 subjects) and in homogeneous …

Opioids have multiple effects on sleep, sleep architecture and SDB. Although originally
described with methadone use, most commonly used opioids have also been shown to …

Opioids are commonly used for pain management, perioperative procedures, and addiction
treatment. There is a current opioid epidemic in North America that is paralleled by a marked …

Opioid use continues to rise globally. So too do the associated adverse consequences.
Opioid use disorder (OUD) is a chronic and relapsing brain disease characterized by loss of …

Medication-induced central sleep apnea (CSA) is one of the eight categories of causes of
CSA but in the absence of awareness and careful history may be misclassified as primary …

Study Objectives: The development of restless legs syndrome (RLS) has been rarely
reported during and following opioid withdrawal. We aimed to determine the presence and …