Temporomandibular disorders (TMD) are a group of musculoskeletal diseases affecting
masticatory muscles and temporomandibular joints (TMJ). In this context, the chronic TMD …

Reactive oxygen species (ROS) and the closely related reactive nitrogen species (RNS) are
often generated in applications of atmospheric pressure plasmas intended for biomedical …

(1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak …

To date, the application of oxygen-ozone (O2O3) therapy has significantly increased in the
common clinical practice in several pathological conditions. However, beyond the favorable …

The aim of this review is to dispel misconceptions and skepticism regarding ozone therapy
and to clarify the biochemical and pharmacological mechanisms of action of ozone …

The potential mechanisms of action of ozone therapy are reviewed in this paper. The
therapeutic efficacy of ozone therapy may be partly due the controlled and moderate …

After five decades characterized by empiricism and several pitfalls, some of the basic
mechanisms of action of ozone in pulmonary toxicology and in medicine have been clarified …

OBJECTIVES:(1) To systematically review the clinical application and remineralization
potentials of ozone in dentistry;(2) To summarize the available in vitro applications of ozone …

Modern strategies in drug development employ in silico techniques in the design of
compounds as well as estimations of pharmacokinetics, pharmacodynamics and toxicity …

Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …