[HTML][HTML] Humoral immune escape by current SARS-CoV-2 variants BA. 2.86 and JN. 1, December 2023

LM Jeworowski, B Mühlemann, F Walper… - …, 2024 - eurosurveillance.org
Variant BA. 2.86 and its descendant, JN. 1, of SARS-CoV-2 are rising in incidence across
Europe and globally. We isolated recent JN. 1, BA. 2.86, EG. 5, XBB. 1.5 and earlier variants …

Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA. 2.86 variant

R Nesamari, MA Omondi, R Baguma, MA Höft… - Cell host & …, 2024 - cell.com
Ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has
given rise to recombinant Omicron lineages that dominate globally (XBB. 1), as well as the …

[HTML][HTML] Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - biorxiv, 2023 - ncbi.nlm.nih.gov
SARS-CoV-2 variants acquire mutations in spike that promote immune evasion and impact
other properties that contribute to viral fitness such as ACE2 receptor binding and cell entry …

Emerging variants develop total escape from potent monoclonal antibodies induced by BA. 4/5 infection

C Liu, R Das, A Dijokaite-Guraliuc, D Zhou… - Nature …, 2024 - nature.com
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody
response in the face of high levels of immunity. Here, we isolate spike (S) binding …

SARS-CoV-2 Omicron: Viral Evolution, Immune Evasion, and Alternative Durable Therapeutic Strategies

H Guo, S Ha, JW Botten, K Xu, N Zhang, Z An… - Viruses, 2024 - mdpi.com
Since the SARS-CoV-2 Omicron virus has gained dominance worldwide, its continual
evolution with unpredictable mutations and patterns has revoked all authorized …

AlphaFold2-Enabled Atomistic Modeling of Structure, Conformational Ensembles, and Binding Energetics of the SARS-CoV-2 Omicron BA. 2.86 Spike Protein with …

N Raisinghani, M Alshahrani, G Gupta… - Journal of Chemical …, 2024 - ACS Publications
The latest wave of SARS-CoV-2 Omicron variants displayed a growth advantage and
increased viral fitness through convergent evolution of functional hotspots that work …

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades

B Dadonaite, J Brown, TE McMahon, AG Farrell… - Nature, 2024 - nature.com
SARS-CoV-2 variants acquire mutations in the spike protein that promote immune evasion
and affect other properties that contribute to viral fitness, such as ACE2 receptor binding and …

Efficient overexpression and purification of severe acute respiratory syndrome coronavirus 2 nucleocapsid proteins in Escherichia coli

EL Brudenell, MB Pohare, D Zafred, J Phipps… - Biochemical …, 2024 - portlandpress.com
The fundamental biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
nucleocapsid protein (Ncap), its use in diagnostic assays and its potential application as a …

The spike protein of the apathogenic Beaudette strain of avian coronavirus can elicit a protective immune response against a virulent M41 challenge

S Keep, P Stevenson-Leggett, I Webb, A Fones, J Kirk… - Plos one, 2024 - journals.plos.org
The avian Gammacoronavirus infectious bronchitis virus (IBV) causes major economic
losses in the poultry industry as the aetiological agent of infectious bronchitis, a highly …

[HTML][HTML] Combining genomic data and infection estimates to characterize the complex dynamics of SARS-CoV-2 Omicron variants in the US

R Lopes, K Pham, F Klaassen, MH Chitwood, AM Hahn… - Cell Reports, 2024 - Elsevier
Omicron surged as a variant of concern in late 2021. Several distinct Omicron variants
appeared and overtook each other. We combined variant frequencies and infection …