Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC
compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but …

Damage to the intestinal stem cell niche can result from mechanical stress, infections,
chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to …

The intestinal epithelium harbors a remarkable adaptability to undergo injury-induced repair.
A key part of the regenerative response is the transient reprogramming of epithelial cells into …

Paneth cells are versatile secretory cells located in the crypts of Lieberkühn of the small
intestine. In normal conditions, they function as the cornerstones of intestinal health by …

Long-term impacts of diet have been well studied; however, the immediate response of the
intestinal epithelium to a change in nutrients remains poorly understood. We use …