Functional versus chronological age: geriatric assessments to guide decision making in older patients with cancer

E Soto-Perez-de-Celis, D Li, Y Yuan, YM Lau… - The Lancet …, 2018 - thelancet.com
As the worldwide population ages, oncologists are often required to make difficult and
complex decisions regarding the treatment of older people (aged 65 years and older) with …

[HTML][HTML] The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks

JR Aunan, WC Cho, K Søreide - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Cancer statistics for adults aged 85 years and older, 2019

CE DeSantis, KD Miller, W Dale… - CA: a cancer journal …, 2019 - Wiley Online Library
Adults aged 85 years and older, the “oldest old,” are the fastest‐growing age group in the
United States, yet relatively little is known about their cancer burden. Combining data from …

[HTML][HTML] The paradoxical role of cellular senescence in cancer

J Yang, M Liu, D Hong, M Zeng… - Frontiers in cell and …, 2021 - frontiersin.org
Cellular senescence occurs in proliferating cells as a consequence of various triggers
including telomere shortening, DNA damage, and inappropriate expression of oncogenes …

[HTML][HTML] Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

D Rémond, DR Shahar, D Gille, P Pinto, J Kachal… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Although the prevalence of malnutrition in the old age is increasing worldwide a synthetic
understanding of the impact of aging on the intake, digestion, and absorption of nutrients is …

Correlation between mouse age and human age in anti-tumor research: Significance and method establishment

S Wang, X Lai, Y Deng, Y Song - Life sciences, 2020 - Elsevier
Age is closely related with the occurrence and development of tumors, and with treatment
outcomes. To improve the accuracy and rigor of preclinical studies, and to enhance …

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and …

RM De Pablos, AM Espinosa-Oliva… - Pharmacological …, 2019 - Elsevier
Aging is a complex process. It is considered a risk factor for several diseases such as
cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which …

[HTML][HTML] A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence

AC Flor, D Wolfgeher, D Wu, SJ Kron - Cell death discovery, 2017 - nature.com
At their proliferative limit, normal cells arrest and undergo replicative senescence, displaying
large cell size, flat morphology, and senescence-associated beta-galactosidase (SA-β-Gal) …

[HTML][HTML] Preclinical activities of epigallocatechin gallate in signaling pathways in cancer

M Sharifi-Rad, R Pezzani, M Redaelli, M Zorzan… - Molecules, 2020 - mdpi.com
Epigallocatechin gallate (EGCG) is the main bioactive component of catechins
predominantly present in various types of tea. EGCG is well known for a wide spectrum of …

[HTML][HTML] Cellular senescence: a double-edged sword in cancer therapy

S Xiao, D Qin, X Hou, L Tian, Y Yu, R Zhang… - Frontiers in …, 2023 - frontiersin.org
Over the past few decades, cellular senescence has been identified in cancer patients
undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by …