Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

In recent years, there has been great progress in the understanding of tumor biology and its
surrounding microenvironment. Solid tumors create regions with low oxygen levels …

In vivo bioluminescent imaging (BLI) is increasingly being utilized as a method for modern
biological research. This process, which involves the noninvasive interrogation of living …

Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion
distances from the existing vascular supply increases, resulting in hypoxia in the cancer …

Hypoxia, a condition in which the tissue is deprived of adequate oxygen supply, is a salient
feature of various intractable diseases, including rheumatoid arthritis, ischemic stroke, and …

Tumour recurrence frequently occurs after radiotherapy, but the characteristics,
intratumoural localization and post-irradiation behaviour of radioresistant cancer cells …

A central characteristic of many types of cancer is altered energy metabolism processes
such as enhanced glucose uptake and glycolysis and decreased oxidative metabolism. The …

Oxidative stress leads to lipid, carbohydrate, protein and DNA damage in biological systems
and affects cell structure and function. Breast cancer cells are subjected to a high level of …

GPR30, also known as GPER, has been suggested to mediate rapid effects induced by
estrogens in diverse normal and cancer tissues. Hypoxia is a common feature of solid …