Abstract CXC chemokine receptor 4 (CXCR4) has been suggested to play a critical role in
cancer metastasis. Some studies have described CXCR4 nuclear localization in metastatic …

The prognosis of patients with ovarian cancer has remained poor mainly because of
aggressive cancer progression. Since epithelial-mesenchymal transition (EMT) is an …

The tumor hypoxic microenvironment not only induces genetic and epigenetic changes in
tumor cells, immature vessels formation for oxygen demand, but also compromises the …

Hypoxia is a prevalent attribute of the solid tumor microenvironment that promotes the
expression of genes through posttranslational modifications and stabilization of alpha …

Abstract Phosphoglycerate kinase 1 (PGK1) is an essential enzyme that catalyzes
adenosine 5′-triphosphate (ATP) production in aerobic glycolysis. In addition to regulating …

Low-dose radiotherapy (LDR) has shown significant implications for inflaming the
immunosuppressive tumor microenvironment (TME). Surprisingly, we identify that FABP …

Esophageal cancer (EC) is one of the most life-threatening malignancies worldwide.
Esophageal squamous cell carcinoma (ESCC) is the dominant subtype, accounting for …

Normal oxygen level is critical for niches that together with other components of the niche
play vital role in regulating stem or tumor cells behavior. Hypoxia plays an important role in …

Purpose Ionizing radiation can induce mutations in germ cells in various organisms,
including fruit flies and mice. However, currently, there is no clear evidence for the …

Because of the accelerated proliferation of cancer cells and the limited distance that
molecular oxygen can diffuse from functional tumor blood vessels, there appears to be a …