Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …

Obesity, pancreatitis, cardiovascular, gastrointestinal (GI), and liver diseases have all been
linked to the Western lifestyle, characterized by increased unhealthy food consumption and …

Alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in
severe harm to personal health and posing a serious burden to public health. Based on the …

The liver is vulnerable to sepsis, and sepsis‐induced liver injury is closely associated with
poor survival of sepsis patients. Studies have found that the overproduction of reactive …

Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …

Abstract Ethnopharmacological relevance Tiaogan Jiejiu Tongluo Formula (TJTF), a
traditional Chinese medicine formula, is modified from the well-known ancient prescription …

Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …

Background Skeletal muscle atrophy in chronic kidney disease (CKD) leads to a decline in
quality of life and increased risk of morbidity and mortality. We have obtained evidence that …

Liver fibrosis is the most common pathway in most types of chronic liver damage,
characterized by an imbalance of ECM degradation and synthesis. Saikosaponin-d (SSd) …

Background Hepatic fibrosis is the final pathway of chronic liver disease characterized by
excessive accumulation of extracellular matrix (ECM), which eventually develop into …