NLRP3 inflammasome and pyroptosis in liver pathophysiology: The emerging relevance of Nrf2 inducers
L Hurtado-Navarro, D Angosto-Bazarra, P Pelegrín… - Antioxidants, 2022 - mdpi.com
Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …
Targeting inflammasome pathway by polyphenols as a strategy for pancreatitis, gastrointestinal and liver diseases management: an updated review
Obesity, pancreatitis, cardiovascular, gastrointestinal (GI), and liver diseases have all been
linked to the Western lifestyle, characterized by increased unhealthy food consumption and …
linked to the Western lifestyle, characterized by increased unhealthy food consumption and …
Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the …
X Zhang, Z Dong, H Fan, Q Yang, G Yu, E Pan… - Journal of Zhejiang …, 2023 - Springer
Alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in
severe harm to personal health and posing a serious burden to public health. Based on the …
severe harm to personal health and posing a serious burden to public health. Based on the …
Hepatoprotective Effect of Mitochondria‐Targeted Antioxidant Mito‐TEMPO against Lipopolysaccharide‐Induced Liver Injury in Mouse
PF Wang, K Xie, YX Cao, A Zhang - Mediators of inflammation, 2022 - Wiley Online Library
The liver is vulnerable to sepsis, and sepsis‐induced liver injury is closely associated with
poor survival of sepsis patients. Studies have found that the overproduction of reactive …
poor survival of sepsis patients. Studies have found that the overproduction of reactive …
The ameliorative effects of saikosaponin in thioacetamide-induced liver injury and non-alcoholic fatty liver disease in mice
GR Chang, WL Lin, TC Lin, HJ Liao, YW Lu - International journal of …, 2021 - mdpi.com
Liver disorders are a major health concern. Saikosaponin-d (SSd) is an effective active
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …
ingredient extracted from Bupleurum falcatum, a traditional Chinese medicinal plant, with …
Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats
C Fang, J Zhang, J Han, Y Lei, Z Cao, J Pan… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Tiaogan Jiejiu Tongluo Formula (TJTF), a
traditional Chinese medicine formula, is modified from the well-known ancient prescription …
traditional Chinese medicine formula, is modified from the well-known ancient prescription …
Saikosaponin d alleviates liver fibrosis by negatively regulating the ROS/NLRP3 inflammasome through activating the ERβ pathway
K Zhang, L Lin, Y Zhu, N Zhang, M Zhou… - Frontiers in …, 2022 - frontiersin.org
Background and aims: Saikosaponin d (SSd) has a steroidal structure and significant anti-
inflammatory effects. The purpose of this study was to explore the mechanism underlying …
inflammatory effects. The purpose of this study was to explore the mechanism underlying …
[HTML][HTML] Saikosaponin A and D attenuate skeletal muscle atrophy in chronic kidney disease by reducing oxidative stress through activation of PI3K/AKT/Nrf2 pathway
M Huang, Y Yan, Z Deng, L Zhou, M She, Y Yang… - Phytomedicine, 2023 - Elsevier
Background Skeletal muscle atrophy in chronic kidney disease (CKD) leads to a decline in
quality of life and increased risk of morbidity and mortality. We have obtained evidence that …
quality of life and increased risk of morbidity and mortality. We have obtained evidence that …
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway
L Lin, M Zhou, R Que, Y Chen, X Liu… - … and Cell Biology, 2021 - cdnsciencepub.com
Liver fibrosis is the most common pathway in most types of chronic liver damage,
characterized by an imbalance of ECM degradation and synthesis. Saikosaponin-d (SSd) …
characterized by an imbalance of ECM degradation and synthesis. Saikosaponin-d (SSd) …
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling
Y Chen, R Que, N Zhang, L Lin, M Zhou, Y Li - Molecular Biology Reports, 2021 - Springer
Background Hepatic fibrosis is the final pathway of chronic liver disease characterized by
excessive accumulation of extracellular matrix (ECM), which eventually develop into …
excessive accumulation of extracellular matrix (ECM), which eventually develop into …