The origin and functions of mast cells (MCs) have been debated since their description by
Paul Ehrlich in 1879. MCs have long been considered'reactive bystanders' and'amplifiers' in …

Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th)
cell subsets. Th2 cells are central players in immunity to helminths and are implicated in …

В монографии приведены сведения по роли цитокинов в регуляции физиологических
процессов, защитных реакций организма и в патогенезе иммунопатологических …

IgE-dependent mast cell activation is a major effector mechanism underlying the pathology
associated with allergic disorders. The most dramatic of these IgE-associated disorders is …

The immune response is tailored to the environment in which it takes place. Immune cells
sense and adapt to changes in their surroundings, and it is now appreciated that in addition …

Mast cells are haematopoietic cells that arise from pluripotent precursors of the bone
marrow. They play immunomodulatory roles in both health and disease. When appropriately …

IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in
immune defense against parasites, venoms, toxins, etc. However, they are best known for …

Snakebite envenoming is a pathological condition which may occur in response to the
injection of venom. Snake venoms contain a complex mixture of biologically active …

The mechanisms involved in the induction of allergic sensitization by pollen are not fully
understood. Within the last few decades, findings from epidemiological and experimental …

Reactive oxygen species (ROS) are produced both enzymatically and non-enzymatically in
vivo. Physiological concentrations of ROS act as signaling molecules that participate in …