Dystroglycan provides a crucial linkage between the cytoskeleton and the basement
membrane for skeletal muscle cells. Disruption of this linkage leads to various forms of …

Duchenne and Becker muscular dystrophies are collectively termed dystrophinopathy.
Dystrophinopathy and severe childhood autosomal recessive muscular dystrophy …

Dystrophin plays an important role in skeletal muscle by linking the cytoskeleton and the
extracellular matrix. The amino terminus of dystrophin binds to actin and possibly other …

The dystrophin–glycoprotein complex (DGC) is a multisubunit complex that spans the
muscle plasma membrane and forms a link between the F-actin cytoskeleton and the …

In the field of muscular dystrophy, advances in understanding the molecular basis of the
various disorders in this group have been rapidly translated into readily applicable …

The sarcoglycans are transmembrane components of the dystrophin-glycoprotein complex,
which links the cytoskeleton to the extracellular matrix in adult muscle fibers. Mutations in all …

Four unique transmembrane glycoproteins comprise the sarcoglycan complex in striated
muscle. The sarcoglycan complex contributes to maintenance of sarcolemma integrity. A …

We investigated the molecular basis of a severe form of early onset autosomal recessive
muscular dystrophy with sarcoglycan (SG) deficiency in seven large Gypsy families living in …

The sarcoglycans are a complex of four transmembrane proteins (α, β, γ, and δ) which are
primarily expressed in skeletal muscle and are closely associated with dystrophin and the …

The involvement of the sarcoglycan complex in the pathogenesis of muscular dystrophy is
becoming increasingly clear. Sarcoglycan gene mutations lead to four forms of autosomal …