Colorectal cancer (CRC) is highly heterogeneous at the genetic and molecular level, which
has major repercussions on the efficacy of immunotherapy. A small subset of CRCs exhibit …

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …

The incidence of colorectal cancer (CRC) is on the rise, and the prognosis for patients with
recurrent or metastatic disease is extremely poor. Although chemotherapy and radiation …

We are experiencing a revolution in cancer. Advances in screening, targeted and immune
therapies, big data, computational methodologies, and significant new knowledge of cancer …

RNA vaccines traditionally consist of messenger RNA synthesized by in vitro transcription
using a bacteriophage RNA polymerase and template DNA that encodes the antigen (s) of …

The realization that dendritic cells (DCs) orchestrate innate and adaptive immune responses
has stimulated research on harnessing DCs to create more effective vaccines. Early clinical …

Background Gastrointestinal (GI) cancers are the most common human tumors encountered
worldwide. The majority of GI cancers are unresectable at the time of diagnosis, and in the …

Therapeutic options for the treatment of colorectal cancer (CRC) are diverse but still not
always satisfying. Recent success of immune checkpoint inhibition treatment for the …

The recognition that tumors could after all be suffiin the annals of contemporary cancer
immunotherapy. ciently “foreign” to be recognized by the immune system There are three …

The polypeptide component of telomerase (TERT) is an attractive candidate for a broadly
expressed tumor rejection antigen because telomerase is silent in normal tissues but is …