SOXC transcription factors as diagnostic biomarkers and therapeutic targets for arthritis

EA Ahmed, AM Alzahrani - International Journal of Molecular Sciences, 2023 - mdpi.com
Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common disorders that disrupt the
quality of life of millions of people. These two chronic diseases cause damage to the joint …

Osteoarthritis related epigenetic variations in miRNA expression and DNA methylation

L Jin, J Ma, Z Chen, F Wang, Z Li, Z Shang… - BMC Medical …, 2023 - Springer
Osteoarthritis (OA) is chronic arthritis characterized by articular cartilage degradation.
However, a comprehensive regulatory network for OA-related microRNAs and DNA …

Multi-omics molecular biomarkers and database of osteoarthritis

J Li, X Yang, Q Chu, L Xie, Y Ding, X Xu, MP Timko… - Database, 2022 - academic.oup.com
Osteoarthritis (OA) is the most common form of arthritis in the adult population and is a
leading cause of disability. OA-related genetic loci may play an important role in clinical …

Males and females have distinct molecular events in the articular cartilage during knee osteoarthritis

C Li, Z Zheng - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a major public health challenge that imposes a remarkable burden on
the affected individuals and the healthcare system. Based on the clinical observation, males …

mEthAE: an Explainable AutoEncoder for methylation data

S Katz, VAP Martins dos Santos, E Saccenti… - bioRxiv, 2023 - biorxiv.org
Despite the wealth of knowledge generated through epigenome-wide association studies
our understanding of the relationships of CpG sites is still limited, as analysis of DNA …

Biological Functions of Selenoprotein lodothyronine Deiodinase and its Expression in Osteoarthritis

X Ren, L Zhang, B Xin, Q Liu, W Qian… - Chinese Medical Sciences …, 2022 - Elsevier
Objective lodothyronine deiodinases (DIOs) are important selenoproteins that play a key
role in the bone and joint diseases. Osteoarthritis (OA) is the most prevalent joint disease …

Modeling Osteoarthritis Progression with DNA Methylation Patterns from Peripheral Blood Immune Cells

CM Dunn - 2023 - search.proquest.com
Osteoarthritis (OA) is a chronic, degenerative, musculoskeletal disease that is the leading
cause of disability in the United States. OA affects over 32 million adults in the US resulting …