Phenotypes of Metabolic Dysfunction–Associated Steatotic Liver Disease–Associated Hepatocellular Carcinoma

J Rivera-Esteban, S Muñoz-Martínez, M Higuera… - Clinical …, 2024 - Elsevier
Hepatocellular carcinoma (HCC) typically develops as a consequence of liver cirrhosis, but
HCC epidemiology has evolved drastically in recent years. Metabolic dysfunction …

[HTML][HTML] Interplay of Extracellular Vesicles and TLR4 Signaling in Hepatocellular Carcinoma Pathophysiology and Therapeutics

SP Papadakos, K Arvanitakis, IE Stergiou, C Vallilas… - Pharmaceutics, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) stands as a significant contributor to global cancer-related
mortality. Chronic inflammation, often arising from diverse sources such as viral hepatitis …

[HTML][HTML] From MASH to HCC: the role of Gas6/TAM receptors

D Apostolo, LL Ferreira, F Vincenzi… - Frontiers in …, 2024 - frontiersin.org
Metabolic dysfunction-associated steatohepatitis (MASH) is the replacement term for what
used to be called nonalcoholic steatohepatitis (NASH). It is characterized by inflammation …

[HTML][HTML] Identifying Potent Fat Mass and Obesity-Associated Protein Inhibitors Using Deep Learning-Based Hybrid Procedures

K Mayuri, D Varalakshmi, M Tharaheswari… - …, 2024 - mdpi.com
The fat mass and obesity-associated (FTO) protein catalyzes metal-dependent modifications
of nucleic acids, namely the demethylation of methyl adenosine inside mRNA molecules …

[HTML][HTML] Inflammatory Response in the Pathogenesis and Treatment of Hepatocellular Carcinoma: A Double-Edged Weapon

L Galasso, L Cerrito, V Maccauro, F Termite… - International Journal of …, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) is the most frequent among primary liver tumors (90%) and
one of the main causes of cancer-related death. It develops usually in a chronically inflamed …

The parallel lives of pandemics: COVID‑19 and obesity

VE Georgakopoulou… - Experimental and …, 2024 - spandidos-publications.com
The present article discusses the interconnectedness of coronavirus disease 2019 (COVID‑
19) and obesity as global health crises. The similarities between the two conditions are …