It is critical to understand the molecular mechanisms governing the regulation of MITF, a
lineage specific transcription factor in melanocytes and an oncogene in melanoma. We …

The Src-homology 2 domain containing phosphatase 2 (SHP2) plays a critical role in crucial
signaling pathways and is involved in oncogenesis and in developmental disorders. Its …

Background Tyrosine phosphorylation of intracellular proteins is a post‐translational
modification that plays a regulatory role in signal transduction during cellular events …

SHP2 mediates signaling from multiple receptor tyrosine kinases (RTKs) to extracellular
signal-regulated kinase (ERK) and Ser and Thr kinase AKT, and its inhibitors offer an …

Myeloproliferative neoplasms (MPNs), including polycythemia vera, essential
thrombocytosis, and primary myelofibrosis, are clonal hematopoietic neoplasms driven by …

The RAS/mitogen-activated protein kinase (MAPK) pathway disorder induced by the
missense mutations in the tyrosine-protein phosphatase non-receptor type 11 (PTPN11) …

Activation of the Ras pathway is a common finding in pediatric hematologic neoplasms.
Implementation of precision medicine with a goal of improving outcomes for these patients …

NSCLC has a diverse genomic background with mutations in key proto-oncogenic drivers
including Kirsten rat sarcoma (KRAS) and epidermal growth factor receptor (EGFR) …

KRAS-mutant colorectal cancer (CRC) is a highly malignant cancer with a poor prognosis,
however specific therapies targeting KRAS mutations do not yet exist. Anti-epidermal growth …

Protein tyrosine phosphorylation is a post-translational modification that regulates protein
structure to modulate demic organisms' homeostasis and function. This physiological …