Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol
homeostasis has been linked to the development of cancer. The tumor microenvironment …

Advanced colorectal cancer (CRC) is characterized by a high recurrence and metastasis
rate, which is the primary cause of patient mortality. Unfortunately, effective anti‐cancer …

Plasmodium falciparum is a unicellular, intracellular protozoan parasite, and the causative
agent of malaria in humans, a deadly vector borne infectious disease. A key phase of …

Cancer stem cells (CSCs) represent a subpopulation within tumors that promote cancer
progression, metastasis, and recurrence due to their self-renewal capacity and resistance to …

Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …

Covalent bioactive compounds are successfully used in clinic and attracted intense research
efforts in the fundamental study as well as drug development. The advantageous effects of …

Clear cell renal cell carcinoma (ccRCC) is a malignant tumor of the urinary system. To
explore the potential mechanisms of DHODH in ccRCC, we analyzed its molecular …

The current advent explores the potential of itraconazole (ITR) in prostate cancer (PCa), by
its incorporation into albumin nanoparticles (NP). ITR as a repurposed moiety has displayed …

Esophageal cancer is one of the most lethal malignancies worldwide. For locally advanced
diseases, radiotherapy is the main treatment. The survival rates, however, are still appalling …

The prevalence of cancer in 2022, according to World Health Organization (WHO) data, is
20 million new cases and 9.7 deaths. The comparison of death rates based on gender is that …