The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

There has been nearly a century of interest in the idea that encoding and storage of
information in the brain requires changes in the efficacy of synaptic connections between …

Information storage in the brain is a temporally graded process involving different memory
types or phases. It has been assumed for over a century that one or more short-term memory …

Abstract Perturbed Endoplasmic Reticulum (ER) calcium (Ca 2+) homeostasis emerges as a
central player in Alzheimer disease (AD). Accordingly, different studies have reported …

The type 2 ryanodine receptor/calcium release channel (RyR2), required for excitation-
contraction coupling in the heart, is abundant in the brain. Chronic stress induces …

Many experiments in the past have demonstrated the requirement of de novo gene
expression during the long-term retention of learning and memory. Although previous …

Background: Non-dioxin-like (NDL) polychlorinated biphenyls (PCBs) promote dendritic
growth in hippocampal neurons via ryanodine receptor (RyR)-dependent mechanisms; …

The smooth endoplasmic reticulum (SER) is a well-characterized buffer and source of Ca 2+
in both axonal and dendritic compartments of neurons. Ca 2+ release from the SER can be …

The immediate‐early gene Zif268 is a member of the Egr family of inducible transcription
factors. Data from gene expression studies have suggested that this gene may play a critical …

Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents
of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function …