Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …

Cellular senescence: pathogenic mechanisms in lung fibrosis

T Parimon, MS Hohmann, C Yao - International journal of molecular …, 2021 - mdpi.com
Pulmonary fibrosis is a chronic and fatal lung disease that significantly impacts the aging
population globally. To date, anti-fibrotic, immunosuppressive, and other adjunct therapy …

Mesenchymal stem cells in fibrotic diseases—The two sides of the same coin

L Qin, N Liu, C Bao, D Yang, G Ma, W Yi… - Acta Pharmacologica …, 2023 - nature.com
Fibrosis is caused by extensive deposition of extracellular matrix (ECM) components, which
play a crucial role in injury repair. Fibrosis attributes to~ 45% of all deaths worldwide. The …

The emerging roles of interstitial macrophages in pulmonary fibrosis: a perspective from scRNA-seq analyses

Y Gu, T Lawrence, R Mohamed, Y Liang… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the
etiology remains poorly understood. This disease can be lethal and currently has no specific …

Immune cell dysregulation as a mediator of fibrosis in systemic sclerosis

D Fang, B Chen, A Lescoat, D Khanna… - Nature Reviews …, 2022 - nature.com
Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

S100A12 as biomarker of disease severity and prognosis in patients with idiopathic pulmonary fibrosis

Y Li, Y He, S Chen, Q Wang, Y Yang, D Shen… - Frontiers in …, 2022 - frontiersin.org
Background Idiopathic pulmonary fibrosis (IPF) is one of interstitial lung diseases (ILDs) with
poor prognosis. S100 calcium binding protein A12 (S100A12) has been reported as a …

The role of cGAS-STING signaling in pulmonary fibrosis and its therapeutic potential

J Zhang, L Zhang, Y Chen, X Fang, B Li… - Frontiers in …, 2023 - frontiersin.org
Pulmonary fibrosis is a progressive and ultimately fatal lung disease, exhibiting the
excessive production of extracellular matrix and aberrant activation of fibroblast. While …

PD-L1 mediates lung fibroblast to myofibroblast transition through Smad3 and β-catenin signaling pathways

X Guo, C Sunil, O Adeyanju, A Parker, S Huang… - Scientific Reports, 2022 - nature.com
Abstract Programmed death ligand-1 (PD-L1) is an immune checkpoint protein that has
been linked with idiopathic pulmonary fibrosis (IPF) and fibroblast to myofibroblast transition …

Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis

H Ma, S Liu, S Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin
that usually results in death from secondary respiratory failure within 2–5 years of diagnosis …

Tissue‐resident memory T cells and lung immunopathology

IS Cheon, YM Son, J Sun - Immunological Reviews, 2023 - Wiley Online Library
Rapid reaction to microbes invading mucosal tissues is key to protect the host against
disease. Respiratory tissue‐resident memory T (TRM) cells provide superior immunity …