Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Biophysical signals act as potent regulators of stem cell function, lineage commitment, and
epigenetic status. In recent years, synthetic biomaterials have been used to study a wide …

During animal embryogenesis, homeostasis and disease, tissues push and pull on their
surroundings to move forward. Although the force-generating machinery is known, it is …

Glial cells constitute without any dispute an essential element in providing an efficiently
operating nervous system. Work in many labs over the last decades has demonstrated that …

Glia play a crucial role in providing metabolic support to neurons across different species. To
do so, glial cells isolate distinct neuronal compartments from systemic signals and …

Communities of epithelial cells communicate through intercellular interactions, allowing
them to coordinate their motility, which plays a key role in homeostasis, morphogenesis and …

Microglial cells are key players in the primary immune response of the central nervous
system. They are highly active and motile cells that chemically and mechanically interact …

Neuronal growth cones are exquisite sensory-motor machines capable of transducing
features contacted in their local extracellular environment into guided process extension …

The ability of cancer cells to sense external mechanical forces has emerged as a significant
factor in the promotion of cancer invasion. Currently there are conflicting reports in the …