Lung cancer is a main cause of death all over the world with a high incidence rate.
Metastasis into neighboring and distant tissues as well as resistance of cancer cells to …

Evolutionarily conserved Notch plays a critical role in embryonic development and cellular
self-renewal. It has both tumour suppressor and oncogenic activity, the latter of which is …

Gastrointestinal (GI) cancers with a high incidence rate and adverse complications are
related to severe morbidity and mortality around the world. MicroRNAs (miRs) are potential …

Detachment is the initial and critical step for cancer metastasis. Only the cells that survive
from detachment can develop metastases. Following the disruption of cell–extracellular …

Simple Summary Glioma patients that present a somatic mutation in the isocitrate
dehydrogenase 1 (IDH1) gene have a significantly better prognosis and overall survival than …

Simple Summary The dysregulation of Notch signaling plays an important role in cancer
development. Numerous attempts are made to modulate Notch signaling for positive …

Background Gastric cancer is a common malignant tumor of digestive tract. The study aimed
to identify candidate genes associated with the proliferation and survival of gastric cancer …

Objective Gastric cancer (GC) remains a prevailing threat to life. Baicalein exhibits anti-
cancer properties. This study estimated the mechanism of baicalein in GC cell apoptosis by …

Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is widely known as a
tumor suppressor gene. It is located on chromosome 10q23 with 200 kb, and has dual …

The small molecule DAPT inhibits the Notch signaling pathway by blocking γ-secretase
mediated Notch cleavage. Given the critical role of the Notch signaling axis in inflammation …