Animal models of osteoarthritis: classification, update, and measurement of outcomes

EL Kuyinu, G Narayanan, LS Nair… - Journal of orthopaedic …, 2016 - Springer
Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Joint instability and osteoarthritis

D Blalock, A Miller, M Tilley… - Clinical Medicine Insights …, 2015 - journals.sagepub.com
Joint instability creates a clinical and economic burden in the health care system. Injuries
and disorders that directly damage the joint structure or lead to joint instability are highly …

Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis

CM Mazur, JJ Woo, CS Yee, AJ Fields, C Acevedo… - Bone research, 2019 - nature.com
Osteoarthritis (OA), long considered a primary disorder of articular cartilage, is commonly
associated with subchondral bone sclerosis. However, the cellular mechanisms responsible …

The acetabular labrum: a review of its function

S Bsat, H Frei, PE Beaulé - The bone & joint journal, 2016 - boneandjoint.org.uk
The acetabular labrum is a soft-tissue structure which lines the acetabular rim of the hip joint.
Its role in hip joint biomechanics and joint health has been of particular interest over the past …

[HTML][HTML] Non-invasive mouse models of post-traumatic osteoarthritis

BA Christiansen, F Guilak, KA Lockwood… - Osteoarthritis and …, 2015 - Elsevier
Animal models of osteoarthritis (OA) are essential tools for investigating the development of
the disease on a more rapid timeline than human OA. Mice are particularly useful due to the …

Pros and cons of mouse models for studying osteoarthritis

S Bapat, D Hubbard, A Munjal, M Hunter… - Clinical and translational …, 2018 - Springer
Osteoarthritis (OA) is one of the most common chronic conditions in the world today. It results
in breakdown of cartilage in joints and causes the patient to experience intense pain and …

Osteoarthritis: trauma vs disease

G Jiménez, J Cobo-Molinos, C Antich… - … , Current Strategies, and …, 2018 - Springer
Osteoarthritis (OA) is the most prevalent joint disease characterized by pain and
degenerative lesions of the cartilage, subchondral bone, and other joint tissues. The causes …

Using mouse models to investigate the pathophysiology, treatment, and prevention of post‐traumatic osteoarthritis

CL Blaker, EC Clarke, CB Little - Journal of Orthopaedic …, 2017 - Wiley Online Library
Post‐traumatic osteoarthritis (PTOA) is defined by its development after joint injury. Factors
contributing to the risk of PTOA occurring, the rate of progression, and degree of associated …

Animal models of osteoarthritis in small mammals

CI Serra, C Soler - Veterinary Clinics: Exotic Animal …, 2019 - vetexotic.theclinics.com
Osteoarthritis (OA) is the most common joint disease affecting the human population, as well
as most mammals. Around 630 million people worldwide are thought to have this condition …

Early inhibition of subchondral bone remodeling slows load‐induced posttraumatic osteoarthritis development in mice

SN Ziemian, AM Witkowski, TM Wright… - Journal of Bone and …, 2020 - academic.oup.com
Posttraumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral
bone remodeling. Inhibiting altered remodeling immediately following joint damage can …