Prostate cancer is the second most diagnosed form of cancer in men worldwide and
accounted for roughly 1.3 million cases and 359,000 deaths globally in 2018, despite all the …

Guanine nucleotide exchange factors (GEFs) are primarily involved in signal transmission
between cell membrane receptors and intracellular mediators. Upon replacing GDP with …

Prostate cancer (PC) is one of the common malignant tumors of the male genitourinary
system. Here, we constructed PTX@ ZIF-8, which is a metal-organic-framework …

Chemoresistance is a major obstacle in the clinical management of metastatic, castration-
resistant prostate cancer (PCa). It is imperative to develop novel strategies to overcome …

This study aimed to explore the expression, molecular mechanism and its biological function
of potassium two pore domain channel subfamily K member 1 (KCNK1) in bladder cancer …

Prostate cancer (PCa) is a clinically heterogeneous disease with a progressively increasing
incidence. Concurrent inhibition of coactivator-associated arginine methyltransferase 1 …

Simple Summary Prostate cancer (PC) is the most common cancer in men over 65 and the
fifth leading cause of death by cancer in men. Sphingosine 1-phosphate (S1P) is a bioactive …

Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly
associated with therapy resistance and less good patient survival. The chemotherapy …

Bioengineered 3D models that can mimic patient-specific pathologies in vitro are valuable
tools for developing and validating anticancer therapeutics. In this study, microfibrillar …

Although cancer diagnosis and treatment have rapidly advanced in recent decades,
urological malignancies, which have high morbidity and mortality rates, are among the most …