Enteric glial biology, intercellular signalling and roles in gastrointestinal disease

L Seguella, BD Gulbransen - Nature reviews Gastroenterology & …, 2021 - nature.com
One of the most transformative developments in neurogastroenterology is the realization that
many functions normally attributed to enteric neurons involve interactions with enteric glial …

Disorders of the enteric nervous system—a holistic view

B Niesler, S Kuerten, IE Demir… - … reviews Gastroenterology & …, 2021 - nature.com
The enteric nervous system (ENS) is the largest division of the peripheral nervous system
and closely resembles components and functions of the central nervous system. Although …

Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

C Challis, A Hori, TR Sampson, BB Yoo… - Nature …, 2020 - nature.com
Parkinson's disease is a synucleinopathy that is characterized by motor dysfunction, death of
midbrain dopaminergic neurons and accumulation of α-synuclein (α-Syn) aggregates …

Ghrelin, CCK, GLP-1, and PYY (3–36): secretory controls and physiological roles in eating and glycemia in health, obesity, and after RYGB

RE Steinert, C Feinle-Bisset, L Asarian… - Physiological …, 2017 - journals.physiology.org
The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Functional circuits and signal processing in the enteric nervous system

C Fung, P Vanden Berghe - Cellular and Molecular Life Sciences, 2020 - Springer
The enteric nervous system (ENS) is an extensive network comprising millions of neurons
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

KA Sharkey, PL Beck, DM McKay - Nature reviews Gastroenterology & …, 2018 - nature.com
The epithelial lining of the gastrointestinal tract serves as the interface for digestion and
absorption of nutrients and water and as a defensive barrier. The defensive functions of the …

Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine

Z Li, MM Hao, C Van den Haute, V Baekelandt… - Elife, 2019 - elifesciences.org
The enteric nervous system controls a variety of gastrointestinal functions including intestinal
motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but …

Neurons and glia in the enteric nervous system and epithelial barrier function

N Vergnolle, C Cirillo - Physiology, 2018 - journals.physiology.org
The intestinal epithelial barrier is the largest exchange surface between the body and the
external environment. Its functions are regulated by luminal, and also internal, components …

[HTML][HTML] Enteric nervous system assembly: Functional integration within the developing gut

MM Hao, JPP Foong, JC Bornstein, ZL Li… - Developmental …, 2016 - Elsevier
Co-ordinated gastrointestinal function is the result of integrated communication between the
enteric nervous system (ENS) and “effector” cells in the gastrointestinal tract. Unlike smooth …

Structurally defined signaling in neuro‐glia units in the enteric nervous system

W Boesmans, MM Hao, C Fung, Z Li, C Van den Haute… - Glia, 2019 - Wiley Online Library
Coordination of gastrointestinal function relies on joint efforts of enteric neurons and glia,
whose crosstalk is vital for the integration of their activity. To investigate the signaling …