The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …

Astrocytes are an abundantly distributed population of glial cells in the central nervous
system (CNS) that perform myriad functions in the normal and injured/diseased brain …

Importance Factors associated with synapse loss beyond amyloid-β plaques and
neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in …

Astrocytes play an integral role in the development, maturation, and refinement of neuronal
circuits. Astrocytes secrete proteins and lipids that instruct the formation of new synapses …

Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

The past decade has witnessed increasing evidence for a crucial role played by glial cells,
notably astrocytes, in Alzheimer's disease (AD). To provide novel insights into the roles of …

Introduction Astrocyte-synapse bi-directional communication is required for neuronal
development and synaptic plasticity. Astrocytes structurally interact with synapses using their …

Accumulating evidence highlights the involvement of astrocytes in Alzheimer's disease (AD)
progression. We have previously demonstrated that human iPSC-derived astrocytes ingest …

This work aimed at assessing Alzheimer's disease (AD) pathogenesis through the
investigation of the astrocytic role to transduce the load of amyloid-beta (Aβ) into neuronal …

Several studies including ours reported the detrimental effects of extracellular tau oligomers
(ex-oTau) on glutamatergic synaptic transmission and plasticity. Astrocytes greatly …