Metabolic flexibility as an adaptation to energy resources and requirements in health and disease
RL Smith, MR Soeters, RCI Wüst… - Endocrine …, 2018 - academic.oup.com
The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …
Targeting adipose tissue in the treatment of obesity-associated diabetes
CM Kusminski, PE Bickel, PE Scherer - Nature reviews Drug discovery, 2016 - nature.com
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …
[HTML][HTML] Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
IW Asterholm, C Tao, TS Morley, QA Wang… - Cell metabolism, 2014 - cell.com
Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …
Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in nonalcoholic fatty liver disease
V Azzu, M Vacca, S Virtue, M Allison, A Vidal-Puig - Gastroenterology, 2020 - Elsevier
Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Exercise has beneficial effects on human health, including protection against metabolic
disorders such as diabetes. However, the cellular mechanisms underlying these effects are …
disorders such as diabetes. However, the cellular mechanisms underlying these effects are …
[HTML][HTML] Adiponectin: mechanistic insights and clinical implications
AT Turer, PE Scherer - Diabetologia, 2012 - Springer
Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …
Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases
inflammation and promotes cell survival. No unifying mechanism has yet explained how …
inflammation and promotes cell survival. No unifying mechanism has yet explained how …
Adiponectin regulation and function
H Fang, RL Judd - Comprehensive Physiology, 2011 - Wiley Online Library
Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …
large number of endocrine factors which regulate a wide variety of physiological functions …
Metabolically healthy obesity: definitions, determinants and clinical implications
CM Phillips - Reviews in Endocrine and Metabolic Disorders, 2013 - Springer
Obesity is associated with increased risk of developing metabolic syndrome (MetS), type 2
diabetes mellitus (T2DM) and cardiovascular disease (CVD) leading to higher all-cause …
diabetes mellitus (T2DM) and cardiovascular disease (CVD) leading to higher all-cause …
Adipokines as novel biomarkers and regulators of the metabolic syndrome
Y Deng, PE Scherer - Annals of the New York Academy of …, 2010 - Wiley Online Library
Over the past two decades our view of adipose tissue has undergone a dramatic change
from an inert energy storage tissue to an active endocrine organ. Adipose tissue …
from an inert energy storage tissue to an active endocrine organ. Adipose tissue …