The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and
utilization, dependent on availability and requirement, is known as metabolic flexibility. In …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Chronic inflammation constitutes an important link between obesity and its
pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a …

Adipose tissue and the liver play significant roles in the regulation of whole-body energy
homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient …

Exercise has beneficial effects on human health, including protection against metabolic
disorders such as diabetes. However, the cellular mechanisms underlying these effects are …

Adiponectin is an adipocyte-derived secretory protein that has been very widely studied over
the past 15 years. A multitude of different functions have been attributed to this adipokine. It …

The adipocyte-derived secretory factor adiponectin promotes insulin sensitivity, decreases
inflammation and promotes cell survival. No unifying mechanism has yet explained how …

Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Obesity is associated with increased risk of developing metabolic syndrome (MetS), type 2
diabetes mellitus (T2DM) and cardiovascular disease (CVD) leading to higher all-cause …

Over the past two decades our view of adipose tissue has undergone a dramatic change
from an inert energy storage tissue to an active endocrine organ. Adipose tissue …