[HTML][HTML] Hydrogel-enabled, local administration and combinatorial delivery of immunotherapies for cancer treatment

A Erfani, AE Diaz, PS Doyle - Materials Today, 2023 - Elsevier
Throughout the last decade, interventions to engineer the immune system called
immunotherapy have revolutionized the fields of oncology and autoimmune disease …

Hydrogel drug delivery systems for minimally invasive local immunotherapy of cancer

AS Mikhail, R Morhard, M Mauda-Havakuk… - Advanced Drug Delivery …, 2023 - Elsevier
Although systemic immunotherapy has achieved durable responses and improved survival
for certain patients and cancer types, low response rates and immune system-related …

A bright future: advanced nanotechnology-assisted microwave therapy

Y Du, J Zhou, F He, P Zang, H Gong, C Liu, P Yang - Nano Today, 2023 - Elsevier
Microwave has a promising therapeutic future due to its excellent minimally invasive, tissue
penetrating and organ specificity. Microwave-triggered therapeutic technology has received …

Janus silica nanoparticle-based tumor microenvironment modulator for restoring tumor sensitivity to programmed cell death ligand 1 immune checkpoint blockade …

X Lin, F Li, J Guan, X Wang, C Yao, Y Zeng, X Liu - ACS nano, 2023 - ACS Publications
An immunosuppressive tumor microenvironment (TME) with inadequate and exhausted
tumor-infiltrating cytotoxic lymphocytes and abundant cellular immunosuppressors is the …

Metal‐cyclic dinucleotide nanomodulator‐stimulated STING signaling for strengthened radioimmunotherapy of large tumor

D Wang, T Nie, C Huang, Z Chen, X Ma, W Fang… - Small, 2022 - Wiley Online Library
Combined treatment of immunotherapy and radiotherapy shows promising therapeutic
effects for the regression of a variety of cancers. However, even multi‐modality therapies …

A Booster for Radiofrequency Ablation: Advanced Adjuvant Therapy via In Situ Nanovaccine Synergized with Anti-programmed Death Ligand 1 Immunotherapy for …

Z Tian, Q Hu, Z Sun, N Wang, H He, Z Tang, W Chen - Acs Nano, 2023 - ACS Publications
Radiofrequency ablation (RFA) is one of the most common minimally invasive techniques for
treating hepatocellular carcinoma (HCC), which could destroy tumors through hyperthermia …

Intelligent delivery system targeting PD-1/PD-L1 pathway for cancer immunotherapy

N Liu, R Zhang, Q Shi, H Jiang, Q Zhou - Bioorganic Chemistry, 2023 - Elsevier
The drugs targeting the PD-1/PD-L1 pathway have gained abundant clinical applications for
cancer immunotherapy. However, only a part of patients benefit from such immunotherapy …

Programmed Upregulation of HSP70 by Metal‐Organic Frameworks Nanoamplifier for Enhanced Microwave Thermal‐Immunotherapy

W Guo, M Niu, Z Chen, Q Wu, L Tan… - Advanced …, 2022 - Wiley Online Library
Thermotherapy can directly kill tumor cells whilst being accompanied by immune‐enhancing
effects. However, this immune‐enhancing effect suffers from insufficient expression of …

Prepared MW‐Immunosensitizers Precisely Release NO to Downregulate HIF‐1α Expression and Enhance Immunogenic Cell Death

W Guo, Z Chen, Q Wu, L Tan, X Ren, C Fu, F Cao… - Small, 2024 - Wiley Online Library
Microwave thermotherapy (MWTT) has limited its application in the clinic due to its high rate
of metastasis and recurrence after treatment. Nitric oxide (NO) is a gaseous molecule that …

A bio-responsive, cargo-catchable gel for postsurgical tumor treatment via ICD-based immunotherapy

Q Chen, S Zhou, Y Ding, D Chen, NS Dahiru… - Journal of Controlled …, 2022 - Elsevier
Tumor recurrence and metastasis after surgery remain challenges for tumor treatment.
Strategy that can promote the immunogenicity, activate adaptative immune response and …