The compositional asymmetry of biological membranes has attracted significant attention
over the last decade. Harboring more differences from symmetric membranes than …

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints that
affects~ 1% of the human population. Joint swelling and bone erosion, hallmarks of RA …

Glycerophospholipids are synthesized primarily in the cytosolic leaflet of the endoplasmic
reticulum (ER) membrane and must be equilibrated between bilayer leaflets to allow the ER …

Almost all biomembranes are constructed as lipid bilayers and, in almost all of these, the two
opposing monolayers (leaflets) have distinct lipid compositions. This lipid asymmetry arises …

Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a
counterpart of apoptosis for enucleated cells. However, over the recent years, a growing …

Scramblases play a pivotal role in facilitating bidirectional lipid transport across cell
membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular …

Nucleic acid therapeutics have demonstrated substantial potential in combating various
diseases. However, challenges persist, particularly in the delivery of multifunctional nucleic …

Membranes are molecular interfaces that insulate cells from external stresses,
compartmentalize the cytoplasm, and control the flow of nutrients and information. These …

Lipid peroxidation (LPO), the process of membrane lipid oxidation, is a potential new form of
cell death for cancer treatment. However, the radical chain reaction involved in LPO is …

With the diversity of lipid-protein interactions, any observed membrane protein dynamics or
functions directly depend on the lipid bilayer selection. However, the implications of lipid …