Class AG protein-coupled receptors (GPCRs), a superfamily of cell membrane signaling
receptors, moonlight as constitutively active phospholipid scramblases. The plasma …

The synapse is the communication unit of the brain, linking billions of neurons through
trillions of synaptic connections. The lipid landscape of the synaptic membrane underpins …

The two very rare neurodegenerative diseases historically known as the
“neuroacanthocytosis syndromes” are due to mutations of either VPS13A or XK. These are …

Lipid-protein interactions are normally classified as either specific or general. Specific
interactions refer to lipid binding to specific binding sites within a membrane protein, thereby …

Cell-surface exposure of phosphatidylserine (PS) is essential for phagocytic clearance and
blood clotting. Although a calcium-activated phospholipid scramblase (CaPLSase) has long …

Abstract In Saccharomyces cerevisiae, Ras (RAt Sarcoma) activity plays a central role in
mediating the effect of glucose in decreasing stress resistance and longevity, with …

Nonvesicular lipid transport among different membranes or membrane domains plays
crucial roles in lipid homeostasis and organelle biogenesis. However, the forces that drive …

TMEM16F is a calcium-activated phospholipid scramblase and nonselective ion channel,
which allows the movement of lipids bidirectionally across the plasma membrane. While the …

XK-related 8 (XKR8), in complex with the transmembrane glycoprotein basigin, functions as
a phospholipid scramblase activated by the caspase-mediated cleavage or phosphorylation …

The skin's recognised functions may undergo physiological alterations due to ageing,
manifesting as varying degrees of facial wrinkles, diminished tautness, density, and volume …