We have investigated the largest family with PROP1 deficiency reported to date. Eight
patients, aged 17–40 yr, in two sibships with possibly related mothers but no parental …

The pituitary is an organ dual of origin. The anterior lobe (adenohypophysis) is epithelial in
origin, whereas the posterior lobe (neurohypophysis) derives from the neural ectoderm …

Pituitary stalk interruption and ectopic posterior lobe on magnetic resonance imaging (MRI)
are frequently observed in patients with GH deficiency (GHD), but their pathogenesis …

Celebrating more than twenty years as the single best source in the field, this Fifth Edition
has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 …

The pituitary gland is a complex organ secreting six hormones from five different cell types. It
is the end product of a carefully orchestrated pattern of expression of signalling molecules …

The anterior pituitary gland is a central regulator of growth, reproduction and homeostasis,
and is the end-product of a carefully orchestrated pattern of expression of signalling …

Magnetic resonance imaging (MRI) is the radiological examination method of choice for
evaluating hypothalamo‐pituitary‐related endocrine disease and is considered essential in …

Mutations in the prophet of PIT1 gene (PROP1) are the most common cause of multiple
pituitary hormone deficiency in humans; however, the mechanism of PROP1 action is not …

Objective Mutations within the pituitary‐specific paired‐like homeobox gene PROP1 have
been described in 50–100% of patients with familial combined pituitary hormone deficiency …

Mutations in PROP1 account for up to half of the cases of combined pituitary hormone
deficiency that result from known causes. Despite this, few signaling molecules and …