Normal puberty is associated with the onset and progressive activation of the hypothalamic-
pituitary-gonadal (HPG) axis and the resultant development of secondary sexual …

Mutations in the PROP1 gene are responsible for a high proportion of cases of multiple or
combined anterior pituitary hormone deficiencies in humans. The physical and hormonal …

Normal pituitary gland development requires coordination between maintenance of
progenitor cell pools and selection of progenitors for differentiation. The spatial and temporal …

We report a 28‐year‐old‐female who presented with primary amenorrhoea, absence of
puberty, obesity and normal stature. The subject was clearly short as a child, with a height …

Mutations in the pituitary-specific paired-like homeodomain transcription factor, PROP-1,
result in combined pituitary hormone deficiency. We studied a Brazilian girl, offspring of first …

To investigate the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in
patients with combined pituitary hormone deficiency (CPHD) in Turkey. Seventy-six patients …

Background: Non-syndromic combined pituitary hormone deficiency (CPHD) occurs due to
defects in transcription factors that govern early pituitary development and the specification …

Purpose Combined pituitary hormone deficiency (CPHD) is characterized by a malformed or
underdeveloped pituitary gland resulting in an impaired pituitary hormone secretion. Several …

During fetal development of the anterior pituitary gland, a number of sequential processes
occur that effect cell differentiation and proliferation. Molecular anlyses have revealed …

Pituitary development depends on a complex cascade of interacting transcription factors and
signaling molecules. Lesions in this cascade lead to isolated or combined pituitary hormone …